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Denileukin Diftitox Dosage

Applies to the following strengths: 150 mcg/mL

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Lymphoma

9 mcg/kg/day or 18 mcg/kg/day by IV infusion over 30 to 60 minutes for 5 consecutive days every 21 days for 8 cycles.


Use: Treatment of persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL-2 receptor.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


In 2014, marketing of this drug was discontinued in the US.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Reconstitution/preparation techniques:


Cardiovascular: Weight, edema, blood pressure
Laboratory: Serum albumin levels (prior to initiation of each course and more often as clinically indicated)
Ocular: Visual acuity, color vision
Oncologic: CD25 expression of malignant cells (prior to treatment initiation)
Other: Infusion reactions (within 24 hours of infusion administration)

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.