Denileukin diftitox Side Effects
For the Consumer
Applies to denileukin diftitox: parenteral injection concentrate
Side effects include:
Hypoalbuminemia, chills/fever, asthenia, infection, chest pain, hypotension, vasodilation, edema, dyspnea, nausea/vomiting, anorexia, diarrhea, anemia, increase in serum aminotransferase concentrations, dizziness, pain, headache, cough, rash, pruritus.
For Healthcare Professionals
Applies to denileukin diftitox: intravenous solution
Very common (10% or more): Infusion reactions (up to 70.5%), pyrexia (up to 63.6%), rigors (up to 47.3%), fatigue (up to 46.7%), peripheral edema (up to 25.5%), asthenia (up to 18.2%), pain (up to 12.7%), chest pain (up to 12.7%)[Ref]
Very common (10% or more): Capillary leak syndrome (up to 32.5%), hypotension (up to 16.4%)[Ref]
Common (1% to 10%): Visual changes (e.g., visual acuity loss)[Ref]
Very common (10% or more): Rash (up to 24.4%), pruritus (up to 18.2%)[Ref]
Postmarketing reports: Thyroid conditions (hyperthyroidism, thyroiditis, thyrotoxicosis, and hypothyroidism)
Very common (10% or more): Nausea (up to 60%), vomiting (up to 34.5%), diarrhea (up to 22.2%)[Ref]
Very common (10% or more): Increased ALT or increased AST (up to 84%)[Ref]
Very common (10% or more): Anorexia (up to 20%)[Ref]
Very common (10% or more): Myalgia (up to 20%), back pain (up to 18.2%), arthralgia (up to 15.6%)[Ref]
Very common (10% or more): Headache (up to 28.9%), dizziness (up to 12.7%), dysgeusia (up to 10.9%)[Ref]
Very common (10% or more): Cough (up to 20%), upper respiratory tract infection (up to 13.3%), dyspnea (up to 13.3%)[Ref]
1. "Product Information. Ontak (denileukin diftitox)." Ligand Pharmaceuticals, San Diego, CA.
Not all side effects for denileukin diftitox may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about denileukin diftitox
- Side Effects
- During Pregnancy
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- Support Group
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- Drug class: miscellaneous antineoplastics
Other brands: Ontak
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