Nucodine Side Effects
Generic Name: codeine / pseudoephedrine
Note: This document contains side effect information about codeine / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Nucodine.
For the Consumer
Applies to codeine / pseudoephedrine: oral liquid
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad dizziness or passing out.
- Chest pain or pressure or a fast heartbeat.
- Trouble breathing, slow breathing, or shallow breathing.
- Noisy breathing.
- Feeling very sleepy.
- Feeling confused.
- A heartbeat that does not feel normal.
- Hallucinations (seeing or hearing things that are not there).
- Mood changes.
- Very bad belly pain.
- Very bad headache.
- Trouble passing urine.
- Change in eyesight.
- Very upset stomach or throwing up.
- Very hard stools (constipation).
- Feeling very tired or weak.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling nervous and excitable.
- Not able to sleep.
- Hard stools (constipation).
- Feeling sleepy.
- Upset stomach or throwing up.
- Sweating a lot.
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
For Healthcare Professionals
Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.[Ref]
Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness
Frequency not reported: Restlessness, dizziness, weakness, headache, drowsiness, tremor[Ref]
Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation
Frequency not reported: Nausea, vomiting, dry mouth[Ref]
Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation
Frequency not reported: Hallucinations (particularly in children), anxiety, excitability, insomnia[Ref]
Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression
Frequency not reported: Tachycardia, palpitations, cardiac arrhythmias, hypertension, impaired circulation to the extremities[Ref]
Frequency not reported: Rash
Frequency not reported: Fixed drug eruption in the form of erythematous nodular patches, rash[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
Some side effects of Nucodine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about Nucodine (codeine / pseudoephedrine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- 0 Reviews – Add your own review/rating
- Drug class: upper respiratory combinations
Other brands: Codar D
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