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Nucodine Side Effects

Generic name: codeine / pseudoephedrine

Medically reviewed by Drugs.com. Last updated on Jun 22, 2022.

Note: This document contains side effect information about codeine / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name Nucodine.

Applies to codeine/pseudoephedrine: oral capsule, oral liquid, oral syrup.

General

The more commonly reported adverse effects have included nausea, vomiting, and dizziness.[Ref]

Respiratory

Codeine:

Frequency not reported: Respiratory depression[Ref]

Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.[Ref]

Nervous system

Codeine

Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness

Pseudoephedrine:

Frequency not reported: Restlessness, dizziness, weakness, headache, drowsiness, tremor[Ref]

Gastrointestinal

Codeine

Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation

Pseudoephedrine:

Frequency not reported: Nausea, vomiting, dry mouth[Ref]

Patients with chronic ulcerative colitis may experience increased colonic motility, while patients with acute ulcerative colitis have experienced toxic dilation with codeine use.[Ref]

Psychiatric

Codeine

Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation

Pseudoephedrine:

Frequency not reported: Hallucinations (particularly in children), anxiety, excitability, insomnia[Ref]

Cardiovascular

Codeine

Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression

Pseudoephedrine:

Frequency not reported: Tachycardia, palpitations, cardiac arrhythmias, hypertension, impaired circulation to the extremities[Ref]

Dermatologic

Codeine:

Frequency not reported: Rash

Pseudoephedrine:

Frequency not reported: Fixed drug eruption in the form of erythematous nodular patches, rash[Ref]

Genitourinary

Codeine

Frequency not reported: Oliguria, urinary retention, antidiuretic effect

Pseudoephedrine:

Frequency not reported: Urinary retention[Ref]

Hypersensitivity

Codeine

Frequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edema[Ref]

Ocular

Codeine

Frequency not reported: Visual disturbances

Pseudoephedrine:

Frequency not reported: Angle-closure glaucoma[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.