Ngenla Side Effects

Generic name: somatrogon

Medically reviewed by Drugs.com. Last updated on Aug 10, 2024.

Note: This document provides detailed information about Ngenla Side Effects associated with somatrogon. Some dosage forms listed on this page may not apply specifically to the brand name Ngenla.

Applies to somatrogon: subcutaneous solution.

Serious side effects of Ngenla

Along with its needed effects, somatrogon (the active ingredient contained in Ngenla) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking somatrogon:

Other side effects of Ngenla

Some side effects of somatrogon may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to somatrogon: subcutaneous solution.

General adverse events

Adverse reactions occurring in 5% of patients or greater included injection site reactions, nasopharyngitis, headache, pyrexia, anemia, cough, vomiting, hypothyroidism, abdominal pain, rash, and oropharyngeal pain.^[Ref]

Dermatologic

• Common (1% to 10%): Rash generalized
• Frequency not reported: Lipoatrophy

Endocrine

• Common (1% to 10%): Hypothyroidism
• Uncommon (0.1% to 1%): Adrenal insufficiency

Gastrointestinal

• Very common (10% or more): Common (1% to 10%): Vomiting, abdominal pain, tonsillitis
• Frequency not reported (somatropin): Pancreatitis

Hematologic

• Very common (10% or more): Elevated eosinophils, increasing from normal at baseline over 12 months (29%)
• Common (1% to 10%): Anemia

Hypersensitivity

• Frequency not reported (somatropin): Severe systemic hypersensitivity reactions, including anaphylaxis and angioedema

Immunologic

• Very common (10% or more): Anti-drug antibodies (77.1%)

Local

• Very common (10% or more): Injection site reactions (up to 42.2%), including injection site pain (39%), injection site swelling/induration/hypertrophy/inflammation (10%)
• Common (1% to 10%): Injection site erythema, injection site pruritus, injection site hemorrhage

Metabolic

• Common (1% to 10%): Increased blood creatinine phosphokinase
• Frequency not reported: New onset type 2 diabetes mellitus, worsened glycemic control, fluid retention

Musculoskeletal

• Common (1% to 10%): Arthralgia, pain in extremity
• Frequency not reported: Slipped capital femoral epiphysis, progression of scoliosis, myositis

Nervous system

• Very common (10% or more): Headache (up to 16.5%)
• Frequency not reported (somatropin): Intracranial hypertension (with papilledema, visual changes, headache, nausea, and/or vomiting)

Ocular

• Common (1% to 10%): Allergic conjunctivitis

Oncologic

• Frequency not reported (somatropin): New and recurrent malignancy (e.g., intracranial tumors, including meningiomas, as secondary neoplasms)

Other

• Very common (10% or more): Pyrexia (up to 16.5%)
• Common (1% to 10%): Otitis media, ear pain, arthropod bite
• Frequency not reported: Increased risk of mortality in patients with acute critical illness, sudden death in pediatric patients with Prader-Willi syndrome, elevated laboratory tests (e.g., phosphorus, alkaline phosphatase, parathyroid hormone)

Respiratory

• Very common (10% or more): Nasopharyngitis, including rhinitis, pharyngitis, rhinitis allergic, pharyngitis streptococcal, viral pharyngitis (33%)
• Common (1% to 10%): Cough, oropharyngeal pain, bronchitis

See also:

Further information

Ngenla side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer