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Natpara Side Effects

Generic Name: parathyroid hormone

Note: This document contains side effect information about parathyroid hormone. Some of the dosage forms listed on this page may not apply to the brand name Natpara.

In Summary

Common side effects of Natpara include: decreased serum calcium, diarrhea, hypercalcemia, increased serum calcium, increased urine calcium excretion, vomiting, and hypocalcemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to parathyroid hormone: subcutaneous powder for solution

Along with its needed effects, parathyroid hormone (the active ingredient contained in Natpara) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking parathyroid hormone:

More Common

  • Abdominal or stomach cramps or pain
  • blurred vision
  • confusion
  • constipation
  • convulsions
  • depression
  • difficulty with breathing
  • dizziness
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • irregular heartbeats
  • loss of appetite
  • metallic taste
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle weakness
  • nausea
  • nervousness
  • numbness and tingling around the mouth, fingertips, or feet
  • pounding in the ears
  • slow or fast heartbeat
  • thirst
  • tremor
  • unusual tiredness
  • vomiting
  • weight loss

Some side effects of parathyroid hormone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Abnormal or decreased touch sensation
  • body aches or pain
  • chills
  • cough
  • diarrhea
  • difficulty with moving
  • ear congestion
  • fever
  • loss of voice
  • muscle pain or stiffness
  • pain in the joints or neck
  • pain or tenderness around the eyes and cheekbones
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest
  • upper abdominal or stomach pain

For Healthcare Professionals

Applies to parathyroid hormone: subcutaneous powder for injection


Common (1% to 10%): Hypertension[Ref]


Common (1% to 10%): Immunogenicity[Ref]


Common (1% to 10%): Blood 25-hydroxycholecalciferol decreased[Ref]


Common (1% to 10%): Immunogenicity[Ref]


Very common (10% or more): Hypocalcemia (27%), hypercalcemia (19%)[Ref]


Very common (10% or more): Arthralgia (11%), pain in extremity (10%)

Common (1% to 10%): Neck pain[Ref]

Nervous system

Very common (10% or more): Paresthesia (31%), headache (25%), hypoesthesia (14%)

Common (1% to 10%): Facial hypoesthesia[Ref]


Common (1% to 10%): Upper respiratory tract infection, sinusitis[Ref]


1. "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals, Bedminster, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.