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Natpara Side Effects

Generic Name: parathyroid hormone

Note: This page contains side effects data for the generic drug parathyroid hormone. It is possible that some of the dosage forms included below may not apply to the brand name Natpara.

In Summary

Common side effects of Natpara include: decreased serum calcium, diarrhea, hypercalcemia, increased serum calcium, increased urine calcium excretion, vomiting, and hypocalcemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to parathyroid hormone: subcutaneous powder for solution

As well as its needed effects, parathyroid hormone (the active ingredient contained in Natpara) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking parathyroid hormone, check with your doctor immediately:

More common:
  • Abdominal or stomach cramps or pain
  • blurred vision
  • confusion
  • constipation
  • convulsions
  • depression
  • difficulty with breathing
  • dizziness
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • irregular heartbeats
  • loss of appetite
  • metallic taste
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle weakness
  • nausea
  • nervousness
  • numbness and tingling around the mouth, fingertips, or feet
  • pounding in the ears
  • slow or fast heartbeat
  • thirst
  • tremor
  • unusual tiredness
  • vomiting
  • weight loss

Minor Side Effects

Some parathyroid hormone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abnormal or decreased touch sensation
  • body aches or pain
  • chills
  • cough
  • diarrhea
  • difficulty with moving
  • ear congestion
  • fever
  • loss of voice
  • muscle pain or stiffness
  • pain in the joints or neck
  • pain or tenderness around the eyes and cheekbones
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest
  • upper abdominal or stomach pain

For Healthcare Professionals

Applies to parathyroid hormone: subcutaneous powder for injection


Common (1% to 10%): Hypertension[Ref]


Common (1% to 10%): Immunogenicity[Ref]


Common (1% to 10%): Blood 25-hydroxycholecalciferol decreased[Ref]


Common (1% to 10%): Immunogenicity[Ref]


Very common (10% or more): Hypocalcemia (27%), hypercalcemia (19%)[Ref]


Very common (10% or more): Arthralgia (11%), pain in extremity (10%)
Common (1% to 10%): Neck pain[Ref]

Nervous system

Very common (10% or more): Paresthesia (31%), headache (25%), hypoesthesia (14%)
Common (1% to 10%): Facial hypoesthesia[Ref]


Common (1% to 10%): Upper respiratory tract infection, sinusitis[Ref]


1. "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals, Bedminster, NJ.

It is possible that some side effects of Natpara may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.