Natpara Side Effects

Generic name: parathyroid hormone

Medically reviewed by Drugs.com. Last updated on Nov 1, 2024.

Note: This document provides detailed information about Natpara Side Effects associated with parathyroid hormone. Some dosage forms listed on this page may not apply specifically to the brand name Natpara.

Applies to parathyroid hormone: parenteral powder for injection.

Important warnings This medicine can cause some serious health issues

REMS:

FDA approved a REMS for parathyroid hormone to ensure that the benefits outweigh the risks.

The REMS may apply to one or more preparations of parathyroid hormone and consists of the following: elements to assure safe use and implementation system.

See the FDA REMS page ([Web]).

Side effects include:

Paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria, extremity pain, upper respiratory tract infection, upper abdominal pain, sinusitis, decreased 25-hydroxycholecalciferol concentration, hypertension, facial hypoesthesia, neck pain.

For healthcare professionals

Applies to parathyroid hormone: subcutaneous powder for injection.

General adverse events

The more commonly reported adverse reactions have included paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria, and extremity pain.

Metabolic

• Very common (10% or more): Hypocalcemia (27%), hypercalcemia (19%); hypercalciuria (11%)^[Ref]

Hypocalcemia combines reported events of hypocalcemia and blood calcium decreased; hypercalciuria combines reported events of hypercalciuria and urine calcium increased; and hypercalcemia combines reported events of hypercalcemia and blood calcium increased.

During clinical trials, 3 patients receiving this drug required IV fluids to correct hypercalcemia. In the postmarketing period, seizures due to hypocalcemia have been reported. The risk of hypocalcemia increases when this drug is withdrawn.^[Ref]

Nervous system

• Very common (10% or more): Paresthesia (31%), headache (25%), hypoesthesia (14%)
• Common (1% to 10%): Facial hypoesthesia
• Postmarketing reports: Seizures due to hypocalcemia^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity reactions including anaphylaxis, dyspnea, angioedema, urticaria, rash

Cardiovascular

• Common (1% to 10%): Hypertension^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (18%), diarrhea (12%), vomiting (12%)
• Common (1% to 10%): Upper abdominal pain^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (11%), pain in extremity (10%)
• Common (1% to 10%): Neck pain^[Ref]

Immunologic

• Common (1% to 10%): Immunogenicity^[Ref]

Genitourinary

• Common (1% to 10%): Blood 25-hydroxycholecalciferol decreased^[Ref]

Respiratory

• Common (1% to 10%): Upper respiratory tract infection, sinusitis^[Ref]

Further information

Natpara side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer