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Naftifine topical Side Effects

Medically reviewed by Last updated on Mar 20, 2024.

Applies to naftifine topical: topical cream, topical gel/jelly.

Serious side effects of Naftifine topical

Along with its needed effects, naftifine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking naftifine topical:

Less common

Incidence not known

Other side effects of Naftifine topical

Some side effects of naftifine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to naftifine topical: topical cream, topical gel.


The most common side effect reported with the 2% cream was pruritus. The most common side effects reported with the 2% gel were application site reactions.[Ref]


Common (1% to 10%): Burning/stinging, dryness, erythema, pruritus/itching

Uncommon (0.1% to 1%): Rash, skin tenderness

Postmarketing reports: Redness/irritation, erythema/redness, irritation, burning, blisters, crusting, dryness, mild pruritus/itching, rash[Ref]


Common (1% to 10%): Local irritation, application site reactions


Postmarketing reports: Inflammation, maceration, swelling, serous drainage, pain


Postmarketing reports: Leukopenia, agranulocytosis

Nervous system

Postmarketing reports: Headache, dizziness, burning sensation


1. (2001) "Product Information. Naftin (naftifine topical)." Merz Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.