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Menomune A / C / Y / W-135 Side Effects

Generic Name: meningococcal polysaccharide vaccine

Note: This page contains information about the side effects of meningococcal polysaccharide vaccine. Some of the dosage forms included on this document may not apply to the brand name Menomune A / C / Y / W-135.

For the Consumer

Applies to meningococcal polysaccharide vaccine: parenteral for injection for sub-q use, parenteral solution for im use

Side effects include:

MenACWY-D (Menactra®): Injection site reactions (e.g., pain, induration, erythema, swelling), headache, fatigue, malaise, arthralgia, diarrhea, anorexia, chills, fever, vomiting, rash.

MenACWY-CRM (Menveo®): Injection site reactions (tenderness, erythema), irritability, sleepiness, persistent crying, change in eating habits, vomiting, diarrhea in infants 2 through 23 months of age; injection site reactions (pain, erythema, induration), irritability, sleepiness, malaise, headache in children 2 through 10 years of age; injection site pain, headache, myalgia, malaise, nausea in adults and adolescents.

MPSV4 (Menomune®): Injection site reactions (e.g., pain, erythema, induration, swelling), headache, malaise, chills, fever.

Hib-MenCY (MenHibrix®): Injection site reactions (e.g., pain, redness, swelling), systemic effects (e.g., fever, irritability, drowsiness, loss of appetite).

For Healthcare Professionals

Applies to meningococcal polysaccharide vaccine: subcutaneous powder for injection


The most common adverse events were injection site pain, headache, irritability, and diarrhea.[Ref]


Very common (10% or more): Injection site pain (48.1%), injection site redness (16%), injection site induration (11%), injection site tenderness
Common (1% to 10%): Injection site swelling, injection site hematoma
Uncommon (0.1% to 1%): Injection site reaction
Rare (less than 0.1%): Severe local reactions
Postmarketing reports: Extensive limb swelling at the injection site (frequently associated with erythema, sometimes involving the adjacent joint or swelling of the entire injected limb)[Ref]

Nervous system

Very common (10% or more): Headache (41.8%), drowsiness (11.2%)
Uncommon (0.1% to 1%): Hypoesthesia, dizziness
Very rare (less than 0.01%): Somnolence, neurological reactions
Postmarketing reports: Vasovagal syncope, paresthesia, Guillain-Barre syndrome[Ref]


Very common (10% or more): Fatigue (32.3%), malaise (22.3%), fever
Common (1% to 10%): Chills, febrile reactions (>38C)
Postmarketing reports: Asthenia, influenza-like symptoms[Ref]


Very common (10% or more): Irritability (12.2%)
Uncommon (0.1% to 1%): Insomnia, crying[Ref]


Very common (10% or more): Arthralgia (16%)
Uncommon (0.1% to 1%): Myalgia, pain in extremity
Postmarketing reports: Musculoskeletal stiffness[Ref]


Very common (10% or more): Appetite lost
Common (1% to 10%): Anorexia
Postmarketing reports: Decreased appetite[Ref]


Very common (10% or more): Diarrhea (14%)
Common (1% to 10%): Vomiting, nausea[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus
Rare (less than 0.1%): Urticaria, angioedema
Postmarketing reports: Angioneurotic edema[Ref]


Very common (10% or more): Local axillary lymphadenopathy[Ref]


Postmarketing reports: Hypersensitivity (such as rash, urticaria, pruritus, dyspnea, angioedema), allergic reactions (including anaphylactic and anaphylactoid reactions)[Ref]


Uncommon (0.1% to 1%): Upper respiratory tract illness
Rare (less than 0.1%): Wheeze[Ref]


Postmarketing reports: IgA nephropathy[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Menomune (meningococcal polysaccharide vaccine)." Sanofi Pasteur, Toronto, IA.

Not all side effects for Menomune A / C / Y / W-135 may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.