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Meningococcal polysaccharide vaccine Side Effects

For the Consumer

Applies to meningococcal polysaccharide vaccine: subcutaneous powder for injection

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Developing meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction while taking meningococcal polysaccharide vaccine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe weakness or unusual feeling in your arms and legs (may occur 2 to 4 weeks after you receive the vaccine);

  • high fever; or

  • unusual bleeding.

Less serious side effects of meningococcal polysaccharide vaccine may include:

  • low fever, chills;

  • redness, pain, swelling, or a lump where the vaccine was injected;

  • headache; or

  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to meningococcal polysaccharide vaccine: subcutaneous powder for injection

General

The most common adverse events were injection site pain, headache, irritability, and diarrhea.[Ref]

Local

Very common (10% or more): Injection site pain (48.1%), injection site redness (16%), injection site induration (11%), injection site tenderness
Common (1% to 10%): Injection site swelling, injection site hematoma
Uncommon (0.1% to 1%): Injection site reaction
Rare (less than 0.1%): Severe local reactions
Postmarketing reports: Extensive limb swelling at the injection site (frequently associated with erythema, sometimes involving the adjacent joint or swelling of the entire injected limb)[Ref]

Nervous system

Very common (10% or more): Headache (41.8%), drowsiness (11.2%)
Uncommon (0.1% to 1%): Hypoesthesia, dizziness
Very rare (less than 0.01%): Somnolence, neurological reactions
Postmarketing reports: Vasovagal syncope, paresthesia, Guillain-Barre syndrome[Ref]

Other

Very common (10% or more): Fatigue (32.3%), malaise (22.3%), fever
Common (1% to 10%): Chills, febrile reactions (>38C)
Postmarketing reports: Asthenia, influenza-like symptoms[Ref]

Psychiatric

Very common (10% or more): Irritability (12.2%)
Uncommon (0.1% to 1%): Insomnia, crying[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (16%)
Uncommon (0.1% to 1%): Myalgia, pain in extremity
Postmarketing reports: Musculoskeletal stiffness[Ref]

Metabolic

Very common (10% or more): Appetite lost
Common (1% to 10%): Anorexia
Postmarketing reports: Decreased appetite[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (14%)
Common (1% to 10%): Vomiting, nausea[Ref]

Dermatologic

Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus
Rare (less than 0.1%): Urticaria, angioedema
Postmarketing reports: Angioneurotic edema[Ref]

Hematologic

Very common (10% or more): Local axillary lymphadenopathy[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity (such as rash, urticaria, pruritus, dyspnea, angioedema), allergic reactions (including anaphylactic and anaphylactoid reactions)[Ref]

Respiratory

Uncommon (0.1% to 1%): Upper respiratory tract illness
Rare (less than 0.1%): Wheeze[Ref]

Renal

Postmarketing reports: IgA nephropathy[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Menomune (meningococcal polysaccharide vaccine)." Sanofi Pasteur, Toronto, IA.

Not all side effects for meningococcal polysaccharide vaccine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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