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Meningococcal polysaccharide vaccine Side Effects

For the Consumer

Applies to meningococcal polysaccharide vaccine: parenteral for injection for sub-q use, parenteral solution for im use

Side effects include:

MenACWY-D (Menactra®): Injection site reactions (e.g., pain, induration, erythema, swelling), headache, fatigue, malaise, arthralgia, diarrhea, anorexia, chills, fever, vomiting, rash.

MenACWY-CRM (Menveo®): Injection site reactions (tenderness, erythema), irritability, sleepiness, persistent crying, change in eating habits, vomiting, diarrhea in infants 2 through 23 months of age; injection site reactions (pain, erythema, induration), irritability, sleepiness, malaise, headache in children 2 through 10 years of age; injection site pain, headache, myalgia, malaise, nausea in adults and adolescents.

MPSV4 (Menomune®): Injection site reactions (e.g., pain, erythema, induration, swelling), headache, malaise, chills, fever.

Hib-MenCY (MenHibrix®): Injection site reactions (e.g., pain, redness, swelling), systemic effects (e.g., fever, irritability, drowsiness, loss of appetite).

For Healthcare Professionals

Applies to meningococcal polysaccharide vaccine: subcutaneous powder for injection


The most common adverse events were injection site pain, headache, irritability, and diarrhea.[Ref]


Very common (10% or more): Injection site pain (48.1%), injection site redness (16%), injection site induration (11%), injection site tenderness
Common (1% to 10%): Injection site swelling, injection site hematoma
Uncommon (0.1% to 1%): Injection site reaction
Rare (less than 0.1%): Severe local reactions
Postmarketing reports: Extensive limb swelling at the injection site (frequently associated with erythema, sometimes involving the adjacent joint or swelling of the entire injected limb)[Ref]

Nervous system

Very common (10% or more): Headache (41.8%), drowsiness (11.2%)
Uncommon (0.1% to 1%): Hypoesthesia, dizziness
Very rare (less than 0.01%): Somnolence, neurological reactions
Postmarketing reports: Vasovagal syncope, paresthesia, Guillain-Barre syndrome[Ref]


Very common (10% or more): Fatigue (32.3%), malaise (22.3%), fever
Common (1% to 10%): Chills, febrile reactions (>38C)
Postmarketing reports: Asthenia, influenza-like symptoms[Ref]


Very common (10% or more): Irritability (12.2%)
Uncommon (0.1% to 1%): Insomnia, crying[Ref]


Very common (10% or more): Arthralgia (16%)
Uncommon (0.1% to 1%): Myalgia, pain in extremity
Postmarketing reports: Musculoskeletal stiffness[Ref]


Very common (10% or more): Appetite lost
Common (1% to 10%): Anorexia
Postmarketing reports: Decreased appetite[Ref]


Very common (10% or more): Diarrhea (14%)
Common (1% to 10%): Vomiting, nausea[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus
Rare (less than 0.1%): Urticaria, angioedema
Postmarketing reports: Angioneurotic edema[Ref]


Very common (10% or more): Local axillary lymphadenopathy[Ref]


Postmarketing reports: Hypersensitivity (such as rash, urticaria, pruritus, dyspnea, angioedema), allergic reactions (including anaphylactic and anaphylactoid reactions)[Ref]


Uncommon (0.1% to 1%): Upper respiratory tract illness
Rare (less than 0.1%): Wheeze[Ref]


Postmarketing reports: IgA nephropathy[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Menomune (meningococcal polysaccharide vaccine)." Sanofi Pasteur, Toronto, IA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.