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Lymphazurin Side Effects

Generic name: isosulfan blue

Medically reviewed by Last updated on Nov 29, 2022.

Note: This document contains side effect information about isosulfan blue. Some dosage forms listed on this page may not apply to the brand name Lymphazurin.

Applies to isosulfan blue: subcutaneous solution.

Serious side effects of Lymphazurin

Along with its needed effects, isosulfan blue (the active ingredient contained in Lymphazurin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking isosulfan blue:

Less common

  • Cold, clammy skin
  • confusion
  • cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fast, weak pulse
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • shortness of breath
  • skin rash
  • sweating
  • tightness in the chest
  • troubled breathing
  • unusual tiredness or weakness
  • wheezing

Other side effects of Lymphazurin

Some side effects of isosulfan blue may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Blue discoloration of the skin

For Healthcare Professionals

Applies to isosulfan blue: injectable solution.


Hypersensitivity side effects have included life-threatening anaphylactic reactions in up to 2% of patients. Symptoms may include shock, angioedema, urticaria, pruritus, and respiratory distress and occur most often in patients with a personal or family history of bronchial asthma, significant allergies, drug reactions, or previous reactions to triphenylmethane dyes.[Ref]

The patient should be closely monitored for at least 60 minutes after administration of isosulfan blue. Trained personnel should be available to administer emergency care, including resuscitation.[Ref]


Dermatologic side effects have included pruritus, urticaria, angioedema, and transient or long-term blue coloration (tattooing) of the skin.[Ref]

More about Lymphazurin (isosulfan blue)

Patient resources

Professional resources

Related treatment guides


1. "Product Information. Lymphazurin (isosulfan blue)." Hirsch Industries Inc (2009):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.