Loperamide / Simethicone Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 29, 2024.

Applies to loperamide / simethicone: oral tablet, oral tablet chewable.

Gastrointestinal adverse events

• Common (1% to 10%): Constipation, flatulence, vomiting
• Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distention, abdominal pain, dry mouth, dyspepsia, upper abdominal pain
• Rare (0.01% to 0.1%): Ileus (including paralytic ileus), megacolon (including toxic megacolon)^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, dysgeusia, headache
• Uncommon (0.1% to 1%): Somnolence
• Rare (0.01% to 0.1%): Coordination abnormality, depressed level of consciousness, hypertonia, loss of consciousness, stupor
• Frequency not reported: Drowsiness^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash
• Rare (0.01% to 0.1%): Bullous eruptions, erythema multiforme, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria^[Ref]

Other

• Uncommon (0.1% to 1%): Asthenia
• Rare (0.01% to 0.1%): Fatigue
• Frequency not reported: Tiredness^[Ref]

Hypersensitivity

• Rare (0.01% to 0.1%): Anaphylactic reaction, anaphylactic shock, anaphylactoid reaction, angioedema, hypersensitivity reaction^[Ref]

Genitourinary

• Rare (0.01% to 0.1%): Urinary retention^[Ref]

Ocular

• Rare (0.01% to 0.1%): Miosis^[Ref]

See also:

Frequently asked questions

• How long does Imodium stop diarrhea for?

Further information

Loperamide/simethicone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer