Skip to Content

Loperamide / simethicone Pregnancy and Breastfeeding Warnings

Loperamide / simethicone is also known as: Anti-Diarrheal + Anti-Gas, Imodium Multi-Symptom Relief

Loperamide / simethicone Pregnancy Warnings

Animal studies have failed to reveal evidence of teratogenicity or embryofetal toxicity. There are no controlled data in human pregnancy.

This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk, especially during the first trimester.

AU TGA pregnancy category: Not formally assigned to a pregnancy category. This class of drugs is generally exempt from pregnancy classification.
US FDA pregnancy category: Not formally assigned to a pregnancy category. Not formally assigned to a pregnancy category.

See references

Loperamide / simethicone Breastfeeding Warnings

Breastfeeding is not recommended during use of this drug.

Excreted into human milk: Yes (loperamide); No (simethicone)

Comments:
-Loperamide is excreted into human milk in small amounts.
-Simethicone is not orally absorbed.
-The American Academy of Pediatrics considers loperamide compatible with breastfeeding.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):
  4. "Product Information. Imodium Advanced (loperamide-simethicone)." Johnson and Johnson/Merck Consumer, Fort Washington, PA.

References for breastfeeding information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. "Product Information. Imodium Advanced (loperamide-simethicone)." Johnson and Johnson/Merck Consumer, Fort Washington, PA.
  4. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  5. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide