Litfulo Side Effects

Generic name: ritlecitinib

Medically reviewed by Drugs.com. Last updated on Oct 12, 2023.

Note: This document contains side effect information about ritlecitinib. Some dosage forms listed on this page may not apply to the brand name Litfulo.

Applies to ritlecitinib: oral capsule.

Serious side effects of Litfulo

Along with its needed effects, ritlecitinib (the active ingredient contained in Litfulo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ritlecitinib:

Less common

• Burning, itching, and pain in hairy areas, pus at the root of hair
• painful blisters on the trunk of the body

Incidence not known

• Anxiety
• black, tarry stools
• chest pain, discomfort, or tightness
• confusion
• cough or hoarseness
• coughing or spitting up blood
• difficulty breathing
• difficulty in speaking
• dizziness or lightheadedness
• double vision
• fainting
• fast heartbeat
• fever or chills
• general feeling of illness
• headache
• hives, itching, skin rash
• inability to move the arms, legs, or facial muscles
• inability to speak
• lower back or side pain
• muscle aches
• nausea
• night sweats
• pain, redness, or swelling in the arm or leg
• pain or discomfort in the arms, jaw, back, or neck
• painful or difficult urination
• persistent non-healing sore
• pink growth
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• reddish patch or irritated area
• shiny bump
• slow speech
• sore throat
• sudden high fever or low grade fever for months
• sweating
• swollen glands
• tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
• unusual tiredness or weakness
• vomiting
• weight loss
• white, yellow, or waxy scar-like area
• yellow skin and eyes

Other side effects of Litfulo

Some side effects of ritlecitinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea

Less common

• Blemishes on the skin
• pimples
• swelling or inflammation of the mouth

For Healthcare Professionals

Applies to ritlecitinib: oral capsule.

General

The most frequently reported adverse reactions (with an incidence of 1% or greater) include headache, diarrhea, acne, rash, urticaria, folliculitis, pyrexia, atopic dermatitis, dizziness, increased blood creatine phosphokinase, herpes zoster, decreased red blood cell count, and stomatitis.^[Ref]

Dermatologic

Common (1% to 10%): Acne (acne and acne pustular), dermatitis atopic, folliculitis, rash (rash and dermatitis allergic), urticaria^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (diarrhea and frequent bowel movements) (10%)

Common (1% to 10%): Stomatitis^[Ref]

Hematologic

Common (1% to 10%): Decreased red blood cell count

Rare (0.01% to 0.1%): Decreased platelet count, decreased lymphocyte counts, thromboembolic events^[Ref]

Hepatic

Frequency not reported: Liver enzyme elevations^[Ref]

Oncologic

Common (1% to 10%): Malignancy^[Ref]

Other

Common (1% to 10%): Increased blood creatine phosphokinase, herpes zoster, pyrexia^[Ref]

Nervous system

Very common (10% or more): Headache (headache and migraine) (10.8%)

Common (1% to 10%): Dizziness^[Ref]

Frequently asked questions

• What are JAK inhibitors and how do they work?
• Which JAK inhibitors are approved in the U.S?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer