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Lidazone HC Side Effects

Generic name: hydrocortisone / lidocaine topical

Medically reviewed by Last updated on Aug 30, 2021.

Note: This document contains side effect information about hydrocortisone / lidocaine topical. Some of the dosage forms listed on this page may not apply to the brand name Lidazone HC.

For the Consumer

Applies to hydrocortisone/lidocaine topical: cream, gel/jelly

Side effects requiring immediate medical attention

Along with its needed effects, hydrocortisone/lidocaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrocortisone / lidocaine topical:

Incidence not known

  • Burning or stinging sensation of the skin
  • paleness or redness of the skin
  • swelling of the skin

For Healthcare Professionals

Applies to hydrocortisone / lidocaine topical: rectal cream, rectal cream with applicator, rectal gel with applicator, rectal kit, rectal pad, topical cream, topical kit, topical lotion, topical pad


Local side effects have included erythema, edema, transient stinging, burning, transient blanching, and locus of abnormal sensation.

Local side effects associated with topical hydrocortisone have included burning, itching, or irritation, especially if applied to denuded skin or with occlusive dressings. Long-term use of topical corticosteroids may result in skin atrophy and thinning, and the development of striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Allergic contact dermatitis is occasionally reported.[Ref]


Endocrine side effects of topical corticosteroids are rare. Glucose intolerance and hyperglycemia may be induced by corticosteroids. These drugs can rarely suppress the hypothalamic-pituitary-adrenal axis. This suppression is more likely when higher potency topical steroids are used over extensive areas and when occlusive dressings are used.[Ref]

More about Lidazone HC (hydrocortisone / lidocaine topical)

Consumer resources

Other brands
RectaGel HC, Lidocort, Ana-Lex, AnaMantle HC, ... +3 more

Professional resources

Related treatment guides


1. "Product Information. Lida Mantle HC (hydrocortisone-lidocaine topical)." Bradley Pharmaceuticals Inc, Fairfield, NJ.

2. "Product Information. Peranex HC (hydrocortisone-lidocaine topical)." Bradley Pharmaceuticals Inc, Fairfield, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.