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Lexiscan Side Effects

Generic Name: regadenoson

Note: This page contains information about the side effects of regadenoson. Some of the dosage forms included on this document may not apply to the brand name Lexiscan.

In Summary

Common side effects of Lexiscan include: dyspnea and bronchoconstriction. Other side effects include: systolic hypotension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to regadenoson: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by regadenoson (the active ingredient contained in Lexiscan). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking regadenoson, check with your doctor or nurse immediately:

More common:
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • difficult or labored breathing
  • fast or irregular heartbeat
  • nausea
  • sweating
  • tightness in the chest
Incidence not known:
  • Confusion
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat recurrent
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash, hives, or itching skin
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking regadenoson, get emergency help immediately:

Symptoms of overdose:
  • Dizziness
  • feeling of warmth
  • increased heart rate
  • redness of the face, neck, arms, and occasionally, upper chest

Severity: Minor

Some of the side effects that can occur with regadenoson may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Headache
Less common:
  • Change in taste
  • loss of taste
  • stomach soreness or discomfort
Incidence not known:
  • Diarrhea
  • difficulty with moving
  • joint pain
  • muscle aching or cramping

For Healthcare Professionals

Applies to regadenoson: intravenous solution


Respiratory side effects including dyspnea (28%) have been reported.[Ref]

Nervous system

Nervous system side effects including headache (26%) and dizziness (8%) have been reported.[Ref]


Cardiovascular side effects have included tachycardia (22%), flushing (16%), premature ventricular contractions (14%), chest discomfort (13%), angina or ST segment depression (12%), Chest pain (7%), premature atrial contractions (7%), systolic blood pressure decreased greater than 35 mm Hg (7%), ventricular conduction abnormalities (6%) diastolic blood pressure decreased more than 25 mm Hg (4%), first-degree AV block (PR prolongation greater than 220 msec; 3%), second-degree AV block (less than 1%), AV conduction abnormalities (other than AV blocks; less than 1%).[Ref]


Gastrointestinal side effects including nausea (6%), abdominal discomfort (5%), and dysgeusia (5%) have been reported.[Ref]


General side effects including feeling hot (5%) have been reported.[Ref]


1. "Product Information. Lexiscan (regadenoson)." Astellas Pharma US, Inc, Deerfield, IL.

Not all side effects for Lexiscan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.