Lenacapavir Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 22, 2024.
Applies to lenacapavir: oral tablet.
Other dosage forms:
Precautions
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Do not use this medicine together with carbamazepine (Tegretol®), phenytoin (Dilantin®), rifampin (Rifadin®), or St. John’s wort.
Your immune system may get stronger when you start using HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, including pneumonia, herpes, or tuberculosis. Autoimmune disorders (eg, Graves disease, polymyositis, and Guillain-Barré syndrome) may also occur.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of lenacapavir
Along with its needed effects, lenacapavir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lenacapavir:
Incidence not known
- dark urine
- fever
- inability to move the arms and legs
- joint pain
- light-colored stools
- muscle tenderness, weakness, or pain
- nausea and vomiting
- skin rash
- sudden numbness and weakness in the arms and legs
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- weight loss
- yellow eyes and skin
For healthcare professionals
Applies to lenacapavir: oral tablet, subcutaneous solution.
General adverse events
The most common adverse reactions reported in at least 3% patients were nausea and injection site reactions.[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea[Ref]
Hepatic
- Common (1% to 10%): Increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased direct bilirubin[Ref]
Local
- Very common (10% or more): Injection site reactions (65%) [include swelling (36%), pain (31%), erythema (31%), nodule (25%), induration (15%), pruritus (6%), extravasation (3%) discomfort (1%), mass (3%), hematoma (1%), edema (1%) and ulcer (1%)][Ref]
Four percent patients experienced Grade 3 ISRs (erythema, pain, swelling)[Ref]
Metabolic
- Common (1% to 10%): Glycosuria, hyperglycemia, proteinuria[Ref]
Musculoskeletal
- Very common (10% or more): Increased creatinine (13%)[Ref]
See also:
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References
1. (2022) "Product Information. Sunlenca (lenacapavir)." Gilead Sciences
2. (2023) "Product Information. Sunlenca (lenacapavir)." Gilead Sciences Pty Ltd, SUNLENCA Product Inf
More about lenacapavir
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Patient resources
- Lenacapavir drug information
- Lenacapavir (Oral) (Advanced Reading)
- Lenacapavir (Subcutaneous) (Advanced Reading)
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Further information
Lenacapavir side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.