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Krazati Side Effects

Generic name: adagrasib

Medically reviewed by Drugs.com. Last updated on Feb 13, 2025.

Note: This document provides detailed information about Krazati.

Applies to adagrasib: oral tablet Side Effects associated with adagrasib. Some dosage forms listed on this page may not apply specifically to the brand name Krazati.

Applies to adagrasib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause diarrhea, nausea, vomiting, or serious stomach and bowel problems (eg, bleeding, blockage, swelling, narrowing), Check with your doctor right away if you have fever, pain, stomach pain, cramps, or tenderness, watery or bloody diarrhea. Your doctor may give you medicines (eg, diarrhea medicine) to treat it.

This medicine may increase risk of heart rhythm problems, including QT prolongation and torsade de pointes. Check with your doctor right away if you have chest pain or discomfort, irregular or slow heart rate, fainting, or trouble breathing.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause swelling of the lungs (pneumonitis) or interstitial lung disease. These are life-threatening conditions and require immediate medical attention. The symptoms may be similar to the symptoms from lung cancer. Check with your doctor right away if you have new or worsening cough, fever, or trouble breathing.

Talk with your doctor before using this medicine if you plan to have children. Some men and women using this medicine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Krazati

Along with its needed effects, adagrasib (the active ingredient contained in Krazati) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking adagrasib:

More common side effects

  • agitation
  • bloody urine
  • bone pain
  • chest pain, discomfort, or tightness
  • coma
  • confusion
  • constipation
  • cough
  • dark urine
  • decreased amount of urine
  • depression
  • diarrhea
  • dizziness
  • fainting
  • fast heartbeat
  • fever or chills
  • headache
  • hostility
  • increased blood pressure
  • increased thirst
  • irregular or slow heart rate
  • irritability
  • lethargy
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nausea
  • rapid, shallow breathing
  • seizures
  • sneezing
  • sore throat
  • stomach pain, severe
  • stupor
  • swelling
  • swelling of the face, fingers, or lower legs
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain
  • yellow eyes or skin

Less common side effects

  • anxiety
  • blue lips, fingernails, or skin
  • blurred vision
  • coughing up blood
  • decreased appetite
  • decreased urination
  • decreased weight
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • muscle pain or cramps
  • nightmares or unusually vivid dreams
  • pale skin
  • sunken eyes
  • sweating
  • unusual bleeding or bruising
  • wrinkled skin

Rare side effects

  • inability to speak
  • slurred speech
  • stiffness
  • temporary blindness
  • weakness in the arm or legs on one side of the body, sudden and severe

Incidence not known

  • general feeling of discomfort or illness
  • thickening of bronchial secretions

For healthcare professionals

Applies to adagrasib: oral tablet.

General adverse events

The most common adverse reactions with a frequency of 25% or greater were nausea (70%), diarrhea (69%), vomiting (57%), fatigue (55%), musculoskeletal pain (38%), hepatotoxicity (37%), renal impairment (33%), edema (30%), dyspnea (26%), and decreased appetite (29%).

The most common Grade 3 or 4 laboratory abnormalities with a frequency of 2% or greater were decreased lymphocytes (20%), decreased sodium (52%), decreased hemoglobin (51%), increased alanine aminotransferase (4.5%), increased aspartate aminotransferase (4.2%), hypokalemia (3.6%), hyponatremia (3.4%), increased lipase (2.5%), decreased leukocytes (2.5%), decreased neutrophils (2.3%), and increased alkaline phosphatase (2.0%).[Ref]

Gastrointestinal

Cardiovascular

Hematologic

Metabolic

Musculoskeletal

Nervous system

Other

Psychiatric

Renal

Renal impairment includes acute kidney injury and increased blood creatinine.[Ref]

Respiratory

Hepatic

Hepatotoxicity includes, mixed liver injury, increased blood alkaline phosphatase, increased alanine aminotransferase, increased aspartate aminotransferase, increased liver function test, increased blood bilirubin, and increased conjugated bilirubin.[Ref]

See also:

References

1. (2022) "Product Information. Krazati (adagrasib)." Mirati Therapeutics, Inc.

Further information

Krazati side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.