Konvomep Side Effects

Generic name: omeprazole / sodium bicarbonate

Medically reviewed by Drugs.com. Last updated on Apr 27, 2024.

Note: This document provides detailed information about Konvomep.

Applies to omeprazole / sodium bicarbonate: oral capsule, oral packet, oral powder for suspension Side Effects associated with omeprazole / sodium bicarbonate. Some dosage forms listed on this page may not apply specifically to the brand name Konvomep.

Applies to omeprazole / sodium bicarbonate: oral capsule, oral packet, oral powder for suspension.

Precautions

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, check with your doctor.

Do not use this medicine if you are also taking rilpivirine (Edurant®) or products containing rilpivirine (eg, Complera®). Using these medicines together may cause serious side effects.

Tell your doctor if you have Asian relatives, such as Filipino, Chinese, Japanese, Korean, or Taiwanese. You may need a lower dose of this medicine to treat erosive esophagitis.

This medicine is sometimes given together with other medicines to treat ulcers. Be sure you understand about the risks and proper use of any other medicine your doctor gives you together with omeprazole and sodium bicarbonate combination.

Check with your doctor right away if you have a change in frequency of urination or amount of urine, blood in the urine, fever, joint pain, loss of appetite, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or unusual weight gain after receiving this medicine. These could be symptoms of acute tubulointerstitial nephritis.

Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency.

Serious stomach conditions may occur while taking this medicine alone or together with antibiotics. Check with your doctor immediately if you have stomach cramps, bloated feeling, watery and severe diarrhea which may also be bloody sometimes, fever, nausea, vomiting, or unusual tiredness or weakness.

This medicine may increase your risk of having fractures of the hip, wrist, and spine. This is more likely are 50 years of age and older, if you receive high doses of this medicine or use it for one year or more.

Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.

This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are taking this medicine for more than one year, or if you are taking this medicine together with digoxin (Lanoxin®) or certain diuretics or "water pills". Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.

This medicine may cause serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS). Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

This medicine may increase your risk for fundic gland polyps (abnormal tissue growth in the upper part of your stomach). This is more likely if you are receiving this medicine for more than 1 year. Talk to your doctor if you have concerns.

Do not Stop taking omeprazole / sodium bicarbonate without first checking with your doctor, or unless told to do so by your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before you have medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, atazanavir, nelfinavir, Reyataz®, Viracept®) or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St John's wort) or vitamin supplements.

Serious side effects of Konvomep

Along with its needed effects, omeprazole / sodium bicarbonate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking omeprazole / sodium bicarbonate:

Get emergency help immediately if any of the following symptoms of overdose occur while taking omeprazole / sodium bicarbonate:

Symptoms of overdose

• feeling of warmth
• increased sweating
• redness of the face, neck, arms, and occasionally, upper chest

Other side effects of Konvomep

Some side effects of omeprazole / sodium bicarbonate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to omeprazole / sodium bicarbonate: oral capsule, oral powder for reconstitution, oral suspension.

Other adverse events

• Very common (10% or more): Pyrexia (Up to 20.2%)
• Common (1% to 10%): Hyperpyrexia

Omeprazole:

• Common (1% to 10%): Asthenia
• Postmarketing reports: Fatigue, fever, malaise, pain, tinnitus^[Ref]

Metabolic

• Very common (10% or more): Hypokalemia (Up to 12.4%), hyperglycemia NOS (Up to 10.7%), hypomagnesemia (Up to 10.1%)
• Common (1% to 10%): Fluid overload, hyperkalemia, hypernatremia, hypocalcemia, hypoglycemia NOS, hyponatremia, hypophosphatemia
• Frequency not reported: Cyanocobalamin (vitamin B-12) deficiency

Omeprazole:

• Postmarketing reports: Anorexia, hypoglycemia, hypomagnesemia, hyponatremia, weight gain

Sodium Bicarbonate:

• Postmarketing reports: Metabolic acidosis, tetany^[Ref]

Respiratory

• Very common (10% or more): Nosocomial pneumonia (Up to 11.2%)
• Common (1% to 10%): Acute respiratory distress syndrome, respiratory failure
• Uncommon (0.1% to 1%): Pneumothorax NOS

Omeprazole:

• Common (1% to 10%): Cough, upper respiratory infection
• Postmarketing reports: Bronchospasm, epistaxis, pharyngeal pain^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (Up to 10.1%)
• Common (1% to 10%): Anemia NOS, anemia NOS aggravated

Omeprazole:

• Postmarketing reports: Agranulocytosis/fatal agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia^[Ref]

Cardiovascular

• Common (1% to 10%): Atrial fibrillation, bradycardia not otherwise specified (NOS), edema NOS, hypertension NOS, hypotension NOS, supraventricular tachycardia, tachycardia NOS, ventricular tachycardia

Omeprazole:

• Postmarketing reports: Bradycardia, chest pain/angina, elevated blood pressure, palpitation, peripheral edema, tachycardia^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation, diarrhea NOS, gastric hypomobility, oral candidiasis
• Frequency not reported: Clostridium difficile-associated diarrhea, fundic gland polyps, upper gastrointestinal bleeding

Omeprazole:

• Common (1% to 10%): Abdominal pain, acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting
• Postmarketing reports: Abdominal swelling, Clostridium difficile associated diarrhea, dry mouth, esophageal candidiasis, fecal discoloration, gastric fundic gland polyps, irritable colon, mucosal atrophy of the tongue, pancreatitis/fatal pancreatitis, stomatitis^[Ref]

Benign gastric fundic gland polyps occurred rarely and appeared to be reversible when omeprazole was discontinued.^[Ref]

Dermatologic

• Common (1% to 10%): Decubitus ulcer, rash NOS
• Frequency not reported: Cutaneous lupus erythematosus, systemic lupus erythematosus

Omeprazole:

• Common (1% to 10%): Rash
• Postmarketing reports: Alopecia, cutaneous lupus erythematosus, dry skin, erythema multiforme/severe erythema multiforme, hyperhidrosis, photosensitivity, pruritus, purpura and/or petechia with/without rechallenge, severe generalized skin reactions, skin inflammation, Stevens-Johnson syndrome, systemic lupus erythematosus, toxic epidermal necrolysis (TEN)/fatal TEN, urticaria^[Ref]

Hepatic

• Common (1% to 10%): Abnormal liver function tests NOS

Omeprazole:

• Postmarketing reports: Hepatocellular/cholestatic/mixed hepatitis, jaundice, liver failure/fatal liver failure, liver necrosis/fatal liver necrosis, mild to marked elevation of liver function tests (alkaline phosphatase, ALT, AST, gamma-glutamyl transpeptidase), overt liver disease^[Ref]

Immunologic

• Common (1% to 10%): Candidal infection NOS, sepsis NOS^[Ref]

Psychiatric

• Common (1% to 10%): Agitation

Omeprazole:

• Postmarketing reports: Abnormal dreams, aggression, agitation, anxiety, apathy, confusion, depression, hallucinations, insomnia, nervousness, psychiatric disturbances^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection, urinary tract infection NOS

Omeprazole:

• Postmarketing reports: Hematuria, microscopic pyuria, proteinuria, testicular pain, urinary frequency, urinary tract infection^[Ref]

Nervous system

Omeprazole:

• Common (1% to 10%): Headache, dizziness
• Postmarketing reports: Hemifacial dysesthesia, hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo

Sodium Bicarbonate:

• Postmarketing reports: Seizures^[Ref]

Musculoskeletal

• Frequency not reported: Bone fracture

Omeprazole:

• Common (1% to 10%): Back pain
• Postmarketing reports: Bone fracture, joint pain, leg pain, muscle cramps, muscle weakness, myalgia^[Ref]

Ocular

Omeprazole:

• Postmarketing reports: Anterior ischemic optic neuropathy, blurred vision, double vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis^[Ref]

Hypersensitivity

Omeprazole:

• Postmarketing reports: Anaphylactic shock, anaphylaxis, angioedema, hypersensitivity reactions^[Ref]

Renal

• Frequency not reported: Acute interstitial nephritis

Omeprazole:

• Postmarketing reports: Elevated serum creatinine, glycosuria, interstitial nephritis with/without positive rechallenge^[Ref]

Oncologic

Omeprazole:

• Postmarketing reports: Gastroduodenal carcinoids^[Ref]

Gastroduodenal carcinoids have been reported in patients with Zollinger-Ellison syndrome on long-term therapy. This condition may be a manifestation of the underlying condition, which is known to be associated with these tumors.^[Ref]

Endocrine

Omeprazole:

• Postmarketing reports: Gynecomastia^[Ref]

See also:

Further information

Konvomep side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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