Konvomep Side Effects

Generic name: omeprazole / sodium bicarbonate

Medically reviewed by Drugs.com. Last updated on Dec 24, 2022.

Note: This document contains side effect information about omeprazole / sodium bicarbonate. Some dosage forms listed on this page may not apply to the brand name Konvomep.

Applies to omeprazole / sodium bicarbonate: oral capsule, oral packet, oral powder for suspension.

Serious side effects of Konvomep

Along with its needed effects, omeprazole/sodium bicarbonate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking omeprazole / sodium bicarbonate:

More common

Black, tarry stools
bleeding gums
blood in the urine or stools
blurred vision
chest pain or tightness
confusion
cough
decreased urine
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
drowsiness
dry mouth
fainting
fast or irregular heartbeat
fever or chills
headache
increased thirst
lightheadedness
loss of appetite
muscle pain, cramps, spasms, or twitching
nausea or vomiting
nervousness
numbness or tingling in the hands, feet, or lips
pale skin
pinpoint red spots on the skin
pounding in the ears
rapid, shallow breathing
seizures
slow heartbeat
sneezing
sore throat
sweating
trembling
trouble breathing
unusual bleeding or bruising
unusual tiredness or weakness

Less common

Bladder pain
blue lips, fingernails, or skin
bone pain
chest discomfort
cloudy urine
coma
decreased urine output
difficult, burning, or painful urination
fast, pounding, or irregular heartbeat or pulse
frequent urge to urinate
headache
irregular, fast or slow, or shallow breathing
irritability
lower back or side pain
muscle cramps in the hands, arms, feet, legs, or face
restlessness
stomach cramps or pain
swelling of the face, feet, lower legs, ankles, or hands
weakness or heaviness of the legs

Rare

Severe pain in the chest
sudden onset of severe breathing difficulty

Incidence not known

Arm, back, or jaw pain
blistering, peeling, or loosening of the skin
bloating or swelling of the face, arms, hands, lower legs, or feet
chest tightness or heaviness
constipation
cough or hoarseness
dark-colored urine
diarrhea
difficulty with swallowing
fever with or without chills
general body swelling
general feeling of tiredness or weakness
greatly decreased frequency of urination or amount of urine
high fever
hives or skin rash
indigestion
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
mood or mental changes
noisy breathing
nosebleeds
pain with swallowing
pains in the stomach, side, or abdomen, possibly radiating to the back
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rapid weight gain
red skin lesions, often with a purple center
red, irritated eyes
sores, ulcers, or white spots on the lips or in the mouth
stomach pain, continuing
sweating
swollen glands
unexplained bleeding or bruising
unusual weight gain or loss
weight gain
yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking omeprazole / sodium bicarbonate:

Symptoms of overdose

Feeling of warmth
increased sweating
redness of the face, neck, arms, and occasionally, upper chest

Other side effects of Konvomep

Some side effects of omeprazole / sodium bicarbonate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Agitation
cold sweats
cool, pale skin
depression
excess air or gas in the stomach or intestines
flushed, dry skin
fruit-like breath odor
full feeling
increased hunger
increased thirst
increased urination
lack or loss of strength
nightmares
passing gas
shakiness
slurred speech
white patches in the mouth or throat or on the tongue
white patches with diaper rash

Incidence not known

Abnormal dreams
attack, assault, or force
bad, unusual, or unpleasant (after) taste
blindness
blue-yellow color blindness
change in taste
continuing ringing or buzzing or other unexplained noise in the ears
decreased interest in sexual intercourse
decreased vision
double vision
dry eyes or skin
eye pain
feeling of constant movement of self or surroundings
general feeling of discomfort or illness
hair loss or thinning of the hair
hearing loss
hives or welts
inability to have or keep an erection
increased sensitivity of the skin to sunlight
itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use
lack of feeling or emotion
loss in sexual ability, desire, drive, or performance
pain in the testes
pinpoint red or purple spots on the skin
redness or other discoloration of the skin
seeing, hearing, or feeling things that are not there
sensation of spinning
severe sunburn
sleepiness or unusual drowsiness
sugar in the urine
swelling of the breasts or breast soreness in both females and males
swelling or inflammation of the mouth
trouble sleeping
uncaring

For Healthcare Professionals

Applies to omeprazole / sodium bicarbonate: oral capsule, oral powder for reconstitution, oral suspension.

Other

Very common (10% or more): Pyrexia (Up to 20.2%)

Common (1% to 10%): Hyperpyrexia

Omeprazole:

Common (1% to 10%): Asthenia

Postmarketing reports: Fatigue, fever, malaise, pain, tinnitus^[Ref]

Metabolic

Very common (10% or more): Hypokalemia (Up to 12.4%), hyperglycemia NOS (Up to 10.7%), hypomagnesemia (Up to 10.1%)

Common (1% to 10%): Fluid overload, hyperkalemia, hypernatremia, hypocalcemia, hypoglycemia NOS, hyponatremia, hypophosphatemia

Frequency not reported: Cyanocobalamin (vitamin B-12) deficiency

Omeprazole:

Postmarketing reports: Anorexia, hypoglycemia, hypomagnesemia, hyponatremia, weight gain

Sodium Bicarbonate:

Postmarketing reports: Metabolic acidosis, tetany^[Ref]

Respiratory

Very common (10% or more): Nosocomial pneumonia (Up to 11.2%)

Common (1% to 10%): Acute respiratory distress syndrome, respiratory failure

Uncommon (0.1% to 1%): Pneumothorax NOS

Omeprazole:

Common (1% to 10%): Cough, upper respiratory infection

Postmarketing reports: Bronchospasm, epistaxis, pharyngeal pain^[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia (Up to 10.1%)

Common (1% to 10%): Anemia NOS, anemia NOS aggravated

Omeprazole:

Postmarketing reports: Agranulocytosis/fatal agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia^[Ref]

Cardiovascular

Common (1% to 10%): Atrial fibrillation, bradycardia not otherwise specified (NOS), edema NOS, hypertension NOS, hypotension NOS, supraventricular tachycardia, tachycardia NOS, ventricular tachycardia

Omeprazole:

Postmarketing reports: Bradycardia, chest pain/angina, elevated blood pressure, palpitation, peripheral edema, tachycardia^[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, diarrhea NOS, gastric hypomobility, oral candidiasis

Frequency not reported: Clostridium difficile-associated diarrhea, fundic gland polyps, upper gastrointestinal bleeding

Omeprazole:

Common (1% to 10%): Abdominal pain, acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting

Postmarketing reports: Abdominal swelling, Clostridium difficile associated diarrhea, dry mouth, esophageal candidiasis, fecal discoloration, gastric fundic gland polyps, irritable colon, mucosal atrophy of the tongue, pancreatitis/fatal pancreatitis, stomatitis^[Ref]

Benign gastric fundic gland polyps occurred rarely and appeared to be reversible when omeprazole was discontinued.^[Ref]

Dermatologic

Common (1% to 10%): Decubitus ulcer, rash NOS

Frequency not reported: Cutaneous lupus erythematosus, systemic lupus erythematosus

Omeprazole:

Common (1% to 10%): Rash

Postmarketing reports: Alopecia, cutaneous lupus erythematosus, dry skin, erythema multiforme/severe erythema multiforme, hyperhidrosis, photosensitivity, pruritus, purpura and/or petechia with/without rechallenge, severe generalized skin reactions, skin inflammation, Stevens-Johnson syndrome, systemic lupus erythematosus, toxic epidermal necrolysis (TEN)/fatal TEN, urticaria^[Ref]

Hepatic

Common (1% to 10%): Abnormal liver function tests NOS

Omeprazole:

Postmarketing reports: Hepatocellular/cholestatic/mixed hepatitis, jaundice, liver failure/fatal liver failure, liver necrosis/fatal liver necrosis, mild to marked elevation of liver function tests (alkaline phosphatase, ALT, AST, gamma-glutamyl transpeptidase), overt liver disease^[Ref]

Immunologic

Common (1% to 10%): Candidal infection NOS, sepsis NOS^[Ref]

Psychiatric

Common (1% to 10%): Agitation

Omeprazole:

Postmarketing reports: Abnormal dreams, aggression, agitation, anxiety, apathy, confusion, depression, hallucinations, insomnia, nervousness, psychiatric disturbances^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, urinary tract infection NOS

Omeprazole:

Postmarketing reports: Hematuria, microscopic pyuria, proteinuria, testicular pain, urinary frequency, urinary tract infection^[Ref]

Nervous system

Omeprazole:

Common (1% to 10%): Headache, dizziness

Postmarketing reports: Hemifacial dysesthesia, hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo

Sodium Bicarbonate:

Postmarketing reports: Seizures^[Ref]

Musculoskeletal

Frequency not reported: Bone fracture

Omeprazole:

Common (1% to 10%): Back pain

Postmarketing reports: Bone fracture, joint pain, leg pain, muscle cramps, muscle weakness, myalgia^[Ref]

Ocular

Omeprazole:

Postmarketing reports: Anterior ischemic optic neuropathy, blurred vision, double vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis^[Ref]

Hypersensitivity

Omeprazole:

Postmarketing reports: Anaphylactic shock, anaphylaxis, angioedema, hypersensitivity reactions^[Ref]

Renal

Frequency not reported: Acute interstitial nephritis

Omeprazole:

Postmarketing reports: Elevated serum creatinine, glycosuria, interstitial nephritis with/without positive rechallenge^[Ref]

Oncologic

Gastroduodenal carcinoids have been reported in patients with Zollinger-Ellison syndrome on long-term therapy. This condition may be a manifestation of the underlying condition, which is known to be associated with these tumors.^[Ref]

Omeprazole:

Postmarketing reports: Gastroduodenal carcinoids^[Ref]