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Kemstro Side Effects

Generic Name: baclofen

Note: This document contains side effect information about baclofen. Some of the dosage forms listed on this page may not apply to the brand name Kemstro.

For the Consumer

Applies to baclofen: oral powder for suspension, oral tablet

Along with its needed effects, baclofen (the active ingredient contained in Kemstro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking baclofen:

Less common or rare
  • Bloody or dark urine
  • chest pain
  • fainting
  • hallucinations (seeing or hearing things that are not there)
  • mental depression or other mood changes
  • ringing or buzzing in the ears
  • skin rash or itching
Symptoms of overdose
  • Blurred or double vision
  • convulsions (seizures)
  • muscle weakness (severe)
  • shortness of breath or unusually slow or troubled breathing
  • vomiting

Some side effects of baclofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Confusion
  • dizziness or lightheadedness
  • drowsiness
  • nausea
  • unusual weakness, especially muscle weakness
Less common or rare
  • Abdominal or stomach pain or discomfort
  • clumsiness, unsteadiness, trembling, or other problems with muscle control
  • constipation
  • diarrhea
  • difficult or painful urination or decrease in amount of urine
  • false sense of well-being
  • frequent urge to urinate or uncontrolled urination
  • headache
  • loss of appetite
  • low blood pressure
  • muscle or joint pain
  • numbness or tingling in hands or feet
  • pounding heartbeat
  • sexual problems in males
  • slurred speech or other speech problems
  • stuffy nose
  • swelling of ankles
  • trouble in sleeping
  • unexplained muscle stiffness
  • unusual excitement
  • unusual tiredness
  • weight gain

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Convulsions (seizures)
  • hallucinations (seeing or hearing things that are not there)
  • increase in muscle spasm, cramping, or tightness
  • mood or mental changes
  • unusual nervousness or restlessness

For Healthcare Professionals

Applies to baclofen: compounding powder, intrathecal solution, oral suspension, oral tablet

Cardiovascular

Common (1% to 10%): Cardiac output decreased, hypotension, hypertension, diminished cardiovascular functions, peripheral edema
Rare (less than 0.1%): Arrhythmias, palpitations, chest pain
Frequency not reported: Bradycardia, orthostatic hypotension[Ref]

Dermatologic

Common (1% to 10%): Rash, hyperhidrosis, urticaria/pruritus, facial edema
Uncommon (0.1% to 1%): Alopecia, diaphoresis
Frequency not reported: Rash, sweating, contact dermatitis, skin ulcer[Ref]

Endocrine

Common (1% to 10%): Ovarian cysts are palpable in 4% of women treated with for up to one year[Ref]

Gastrointestinal

Very common (10% or more): Nausea (especially at start of therapy) (up to 11%)
Common (1% to 10%): Dry mouth, GI disorder/disturbance, constipation, diarrhea, retching, vomiting, increased salivation
Uncommon (0.1% to 1%): Dysphagia, dehydration, ileus, decreased taste sensation
Rare (less than 0.1%): Colicky abdominal pain, anorexia
Frequency not reported: GI hemorrhage[Ref]

Genitourinary

Very common (10% or more): Urinary retention (up to 12%)
Common (1% to 10%): Urinary incontinence, urination impaired, sexual dysfunction, urinary frequency, enuresis, dysuria
Rare (less than 0.1%): Erectile dysfunction
Frequency not reported: Dysuria, abnormal ejaculation, oliguria, vaginitis[Ref]

Hematologic

Frequency not reported: Leukocytosis, petechial rash[Ref]

Hepatic

Rare (less than 0.1%): Disorders of hepatic function (e.g., increased AST)[Ref]

Immunologic

Common (1% to 10%): Pneumonia
Uncommon (0.1% to 1%): Septicemia[Ref]

Metabolic

Common (1% to 10%): Decreased appetite
Frequency not reported: Blood glucose increased[Ref]

Musculoskeletal

Very common (10% or more): Hypotonia (up to 52%), lower extremity weakness (up to 15%), disturbances of gait and balance
Common (1% to 10%): Muscular weakness, myalgia, upper extremity weakness, back pain, muscular hypertonia[Ref]

Nervous system

Very common (10% or more): Somnolence (up to 28%), drowsiness (up to 18%), headache (up to 16%), seizures (especially on discontinuation of therapy) (up to 15%), sedation, dizziness (up to 12%)
Common (1% to 10%): Fatigue, ataxia, tremor, lightheadedness, lassitude, exhaustion, numbness/itching/tingling, slurred speech, lethargy, hypertonia, paresthesia
Rare (less than 0.1%): Dysarthria, dysgeusia, syncope, dyskinesia, coma, potentially life-threatening withdrawal symptoms (as a result of sudden interruption of drug delivery)[Ref]

Other

Common (1% to 10%): Tinnitus, pain, asthenia
Uncommon (0.1% to 1%): Accidental injury, weight loss
Very rare (less than 0.01%): Hypothermia
Frequency not reported: Drug withdrawal syndrome
Uncommon (0.1% to 1%): Subdural hemorrhage, accidental injury, weight loss[Ref]

Ocular

Common (1% to 10%): Nystagmus, visual impairment, accommodation disorder, blurred vision, double vision, amblyopia[Ref]

Psychiatric

Common (1% to 10%): Confusional state, hallucination, depression, insomnia, euphoric mood, nightmare, personality changes
Uncommon (0.1% to 1%): Memory loss/impairment, suicidal ideation, attempted suicide
Rare (less than 0.1%): Excitement[Ref]

Renal

Very rare (less than 0.01%): Kidney calculus[Ref]

Respiratory

Common (1% to 10%): Respiratory depression, hypoventilation, dyspnea, bradypnea, feeling of pressure in the chest[Ref]

References

1. "Product Information. Lioresal (baclofen)." Medtronic Inc, Minneapolis, MN.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):

4. "Product Information. Lioresal Intrathecal (baclofen)." Medtronic Inc, Minneapolis, MN.

Some side effects of Kemstro may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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