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Isosulfan blue Side Effects

For the Consumer

Applies to isosulfan blue: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by isosulfan blue. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking isosulfan blue, check with your doctor or nurse immediately:

Less common:
  • Cold, clammy skin
  • confusion
  • cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fast, weak pulse
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • shortness of breath
  • skin rash
  • sweating
  • tightness in the chest
  • troubled breathing
  • unusual tiredness or weakness
  • wheezing

Minor Side Effects

Some of the side effects that can occur with isosulfan blue may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Blue discoloration of the skin

For Healthcare Professionals

Applies to isosulfan blue: injectable solution


Hypersensitivity side effects have included life-threatening anaphylactic reactions in up to 2% of patients. Symptoms may include shock, angioedema, urticaria, pruritus, and respiratory distress and occur most often in patients with a personal or family history of bronchial asthma, significant allergies, drug reactions, or previous reactions to triphenylmethane dyes.[Ref]

The patient should be closely monitored for at least 60 minutes after administration of isosulfan blue. Trained personnel should be available to administer emergency care, including resuscitation.[Ref]


Dermatologic side effects have included pruritus, urticaria, angioedema, and transient or long-term blue coloration (tattooing) of the skin.[Ref]


1. "Product Information. Lymphazurin (isosulfan blue)." Hirsch Industries Inc, Norwalk, CT.

Not all side effects for isosulfan blue may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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