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Ioxaglate Side Effects

Medically reviewed by Last updated on Oct 15, 2023.

Applies to ioxaglate: injectable solution.


The most frequent adverse reactions are nausea, vomiting, facial flush and a feeling of body warmth. These reactions are usually of brief duration. In clinical trials, this drug produced less discomfort (pain and heat) up on injection than other contrast agents.[Ref]


Common (1% to 10%): Facial flushing

Uncommon (0.1% to 1%): Thrombosis

Rare (0.01% to 0.1%): Thrombophlebitis; severe cases of hypotensive shock, coronary insufficiency, cardiac arrhythmia, fibrillation and arrest

Very rare (less than 0.01%): Disseminated intravascular coagulation

Frequency not reported: Generalized vasodilation, flushing, venospasm. Vascular constriction due to injection rate. Cardiac decompensation, serious arrhythmias, myocardial ischemia or infarction may occur during coronary arteriography and left ventriculography.[Ref]


Common (1% to 10%): Nausea, vomiting[Ref]


Uncommon (0.1% to 1%): Thyroid function tests indicative of hypothyroidism or transient thyroid suppression in adults and pediatric patients (including infants)[Ref]


Frequency not reported: Extravasation with burning pain, hematomas, ecchymosis, tissue necrosis[Ref]


Frequency not reported: Dermal manifestations (urticaria with or without pruritus, erythema, maculopapular rash); dry mouth, sweating, conjunctival symptoms; facial, peripheral, and angioneurotic edema; symptoms related to the respiratory system include sneezing, nasal stuffiness, coughing, choking, dyspnea, chest tightness and wheezing, which may be initial manifestations of more severe and infrequent reactions including asthmatic attack, laryngospasm and bronchospasm with or without edema, pulmonary edema, apnea and cyanosis[Ref]

Nervous system

Frequency not reported: Headache, trembling, shaking, lightheadedness, spasm, convulsions, aphasia, syncope, paresis, paralysis resulting from spinal cord injury and pathology associated with the syndrome of transverse myelitis, visual field losses which are usually transient but may be permanent, coma, death[Ref]


Frequency not reported: Chills without fever, hyperthermia[Ref]


Frequency not reported: Temporary renal shutdown or other nephropathy[Ref]


1. Product Information. Hexabrix 200 (ioxaglate). Tyco Healthcare Group Canada Inc. 2015.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.