Ioxaglate Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 3, 2023.

Applies to ioxaglate: injectable solution.

General adverse events

The most frequent adverse reactions are nausea, vomiting, facial flush and a feeling of body warmth. These reactions are usually of brief duration. In clinical trials, this drug produced less discomfort (pain and heat) up on injection than other contrast agents.^[Ref]

Cardiovascular

• Common (1% to 10%): Facial flushing
• Uncommon (0.1% to 1%): Thrombosis
• Rare (0.01% to 0.1%): Thrombophlebitis; severe cases of hypotensive shock, coronary insufficiency, cardiac arrhythmia, fibrillation and arrest
• Very rare (less than 0.01%): Disseminated intravascular coagulation
• Frequency not reported: Generalized vasodilation, flushing, venospasm. Vascular constriction due to injection rate. Cardiac decompensation, serious arrhythmias, myocardial ischemia or infarction may occur during coronary arteriography and left ventriculography.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting^[Ref]

Endocrine

• Uncommon (0.1% to 1%): Thyroid function tests indicative of hypothyroidism or transient thyroid suppression in adults and pediatric patients (including infants)^[Ref]

Dermatologic

• Frequency not reported: Extravasation with burning pain, hematomas, ecchymosis, tissue necrosis^[Ref]

Hypersensitivity

• Frequency not reported: Dermal manifestations (urticaria with or without pruritus, erythema, maculopapular rash); dry mouth, sweating, conjunctival symptoms; facial, peripheral, and angioneurotic edema; symptoms related to the respiratory system include sneezing, nasal stuffiness, coughing, choking, dyspnea, chest tightness and wheezing, which may be initial manifestations of more severe and infrequent reactions including asthmatic attack, laryngospasm and bronchospasm with or without edema, pulmonary edema, apnea and cyanosis^[Ref]

Nervous system

• Frequency not reported: Headache, trembling, shaking, lightheadedness, spasm, convulsions, aphasia, syncope, paresis, paralysis resulting from spinal cord injury and pathology associated with the syndrome of transverse myelitis, visual field losses which are usually transient but may be permanent, coma, death^[Ref]

Other

• Frequency not reported: Chills without fever, hyperthermia^[Ref]

Renal

• Frequency not reported: Temporary renal shutdown or other nephropathy^[Ref]

Further information

Ioxaglate side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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