Iopromide Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 21, 2024.

Applies to iopromide: injection solution.

Precautions

It is very important that your doctor check your or your child's progress closely while you are receiving this medicine to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for any unwanted effects.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, skin rash, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, trouble breathing, or unusual tiredness or weakness after you receive this medicine.

Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis can occur with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, fever, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

This medicine may cause heart attack, stroke, and blood clotting problems. Tell your doctor right away if you or your child has chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness, coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, sudden or severe headache, or problems with vision, speech, or walking after receiving this medicine.

This medicine may cause hypothyroidism (underactive thyroid) in children 3 years of age and younger. Children with congenital (from birth) heart problems may have an increased risk of hypothyroidism. Check with your doctor right away if your child has depressed mood, dry skin and hair, feeling cold, hair loss, hoarseness or a husky voice, muscle cramps and stiffness, slowed heartbeat, weight gain, or unusual tiredness or weakness.

Tell your doctor right away if you or your child have mild, burning pain, feeling of warmth or coldness, peeling of the skin, redness, or swelling at the injection site.

While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of iopromide

Along with its needed effects, iopromide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking iopromide:

Other side effects of iopromide

Some side effects of iopromide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to iopromide: injectable solution.

General adverse events

The most important adverse events were anaphylactoid shock, contrast induced acute kidney injury, coma, cerebral infarction stroke, brain edema, convulsion, arrhythmia, cardiac arrest, myocardial ischemia, myocardial infarction, cardiac failure, bradycardia, cyanosis, hypotension, shock, dyspnea, pulmonary edema, respiratory insufficiency, and aspiration.^[Ref]

Cardiovascular

• Common (1% to 10%): Vasodilatation
• Frequency not reported: Atrioventricular block (complete), bradycardia, ventricular extrasystole, coronary artery thrombosis, flushing, hypertension, hypotension, peripheral vascular disorder, vascular anomaly, myocardial ischemia, cardiac failure, cyanosis, shock
• Postmarketing reports: Cardiac arrest, ventricular fibrillation, atrial fibrillation, tachycardia, palpitations, congestive heart failure, myocardial infarction, angina pectoris, vasospasm^[Ref]

Dermatologic

• Frequency not reported: Hyperhidrosis, face edema, erythema, pruritus, rash urticaria
• Postmarketing reports: Angioedema, mild (e.g. rash, erythema, pruritus, urticaria, skin discoloration) to severe (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis) skin reactions, acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS)^[Ref]

Endocrine

• Postmarketing reports: Hyperthyroidism, thyrotoxic crisis, hypothyroidism^[Ref]

There are uncommon reports of hypothyroidism or transient thyroid suppression after iodinated contrast agents in patients of all ages, including infants. Some patients were treated for hypothyroidism.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting
• Frequency not reported: Abdominal discomfort, abdominal pain, abdominal pain upper, constipation, diarrhea, dry mouth, dyspepsia, gastrointestinal disorder, gastrointestinal pain, salivation increased, stomach discomfort, rectal tenesmus
• Postmarketing reports: Dysphagia, swelling of salivary glands, mucous membrane disorder/mucosal swelling (pediatric patients)^[Ref]

Genitourinary

• Common (1% to 10%): Urinary urgency
• Frequency not reported: Dysuria, blood urea increased, urinary retention
• Postmarketing reports: Hematuria^[Ref]

Hypersensitivity

• Postmarketing reports: Anaphylactoid reactions (including fatal cases), anaphylactoid shock, hypersensitivity^[Ref]

Local

• Common (1% to 10%): Injection site and infusion site reactions (hemorrhage, hematoma, pain, edema, erythema, rash)
• Frequency not reported: Extravasation
• Postmarketing reports: Compartment syndrome in case of extravasation, fixed eruptions (pediatric patients)^[Ref]

Metabolic

• Frequency not reported: Excessive thirst, blood lactate dehydrogenase increased, blood urea increased
• Postmarketing reports: Diabetes insipidus (pediatric patients)^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain
• Frequency not reported: Chills, arthralgia, musculoskeletal pain, myasthenia, neck pain, pain in extremity
• Postmarketing reports: Joint disorder/effusion (pediatric patients), muscle cramps (pediatric patients)^[Ref]

Nervous system

• Common (1% to 10%): Headache, dysgeusia
• Frequency not reported: Convulsion, dizziness, hypertonia, hypesthesia, incoordination, neuropathy, somnolence, speech disorder, tremor, paresthesia, syncope, cerebral infarction stroke, brain edema
• Postmarketing reports: Vertigo, tinnitus, cerebral ischemia/infarction, paralysis, paresis, aphasia, coma, unconsciousness, amnesia, hypotonia, aggravation of myasthenia gravis symptoms, migraine (pediatric patients), brain edema (pediatric patients)^[Ref]

Ocular

• Common (1% to 10%): Abnormal vision
• Frequency not reported: Visual field defect
• Postmarketing reports: Mydriasis, lacrimation disorder, transient cortical blindness^[Ref]

Psychiatric

• Frequency not reported: Agitation, confusion, anxiety^[Ref]

Renal

• Frequency not reported: Renal pain, contrast-induced acute kidney injury
• Postmarketing reports: Renal failure^[Ref]

Respiratory

• Frequency not reported: Asthma, apnea, cough increased, dyspnea, hypoxia, pharyngeal edema, pharyngitis, pleural effusion, pulmonary hypertension, respiratory disorder, sore throat, respiratory insufficiency, aspiration
• Postmarketing reports: Laryngeal edema, laryngospasm, bronchospasm, pulmonary edema, acute respiratory distress syndrome, epistaxis (pediatric patients), hypoxia (pediatric patients)^[Ref]

Hematologic

• Frequency not reported: Hemoglobin increased, white blood cell count increased^[Ref]

Immunologic

• Postmarketing reports: Conjunctivitis (pediatric patients)^[Ref]

Other

• Common (1% to 10%): Chest pain, pain
• Frequency not reported: Asthenia, chest discomfort, feeling hot, malaise, edema peripheral, pyrexia^[Ref]

See also:

Further information

Iopromide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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