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Iopromide Dosage

Applies to the following strengths: 150 mg/mL; 240 mg/mL; 300 mg/mL; 370 mg/mL

Usual Adult Dose for Cerebral Arteriography

Cerebral arteriography, 300 mg Iodine/mL:
-Carotid arteries: 3 to 12 mL
-Vertebral arteries: 4 to 12 mL
-Aortic arch injection (4 vessel study): 20 to 50 mL
Maximum total dose: 150 mL; 86 grams iodine

Comments:
-Volume and rate of injection vary depending on injection site and area being examined.
-Inject at rates approximately equal to the flow rate of the vessel being injected.

Usual Adult Dose for Peripheral Arteriography

Peripheral arteriography, 300 mg Iodine/mL:
-Subclavian or femoral artery: 5 to 40 mL
-Aortic bifurcation: 25 to 50 mL
Maximum total dose: 250 mL; 86 grams iodine

Comments:
-Volume and rate of injection vary depending on injection site and area being examined.
-Inject at rates approximately equal to the flow rate of the vessel being injected.

Usual Adult Dose for Coronary Arteriography

Coronary arteriography and left ventriculography, 370 mg Iodine/mL:
-Right coronary artery: 3 to 14 mL
-Left coronary artery: 3 to 14 mL
-Left ventricle: 30 to 60 mL
Maximum total dose: 225 mL; 86 grams iodine

Comments:
-Volume and rate of injection vary depending on injection site and area being examined.
-Inject at rates approximately equal to the flow rate of the vessel being injected.

Usual Adult Dose for Left Ventriculography

Coronary arteriography and left ventriculography, 370 mg Iodine/mL:
-Right coronary artery: 3 to 14 mL
-Left coronary artery: 3 to 14 mL
-Left ventricle: 30 to 60 mL
Maximum total dose: 225 mL; 86 grams iodine

Comments:
-Volume and rate of injection vary depending on injection site and area being examined.
-Inject at rates approximately equal to the flow rate of the vessel being injected.

Usual Adult Dose for Computed Tomography

Contrast computed tomography, 300 mg Iodine/mL:
-Head: 50 to 200 mL
-Body, single phase contrast: 50 to 200 mL bolus injection, or 100 to 200 mL rapid infusion
-Body, multiple phase contrast: 50 to 200 mL total volume
--Phase 1: 100% contrast
--Phase 2: 20 to 60% contrast, using a power injector suitable for simultaneous contrast and saline injection
Total maximum dose: 200 mL; 60 grams Iodine

Contrast computed tomography, 370 mg Iodine/mL:
-Head: 41 to 162 mL
-Body, single phase contrast: 41 to 162 mL bolus injection, or 81 to 162 mL rapid infusion
-Body, multiple phase contrast: 41 to 162 mL total volume
--Phase 1: 100% contrast
--Phase 2: 20 to 60% contrast, using a power injector suitable for simultaneous contrast and saline injection
Total maximum dose: 162 mL; 60 grams Iodine

Comments:
-Volume and rate of injection vary depending on injection site and area being examined.
-Inject at rates approximately equal to the flow rate of the vessel being injected.

Usual Adult Dose for Urography

Excretory urography, 300 mg Iodine/mL: Approximately 300 mg Iodine per kg body weight (normal renal function patients)
Maximum total dose: 100 mL; 30 grams iodine

Comments:
-Volume and rate of injection vary depending on injection site and area being examined.
-Inject at rates approximately equal to the flow rate of the vessel being injected.

Usual Pediatric Dose for Computed Tomography

2 years and older:
Contrast computerized tomography, 300 mg Iodine/mL: 1 to 2 mL/kg
Maximum dose: 3 mL/kg

Usual Pediatric Dose for Urography

2 years and older:
Contrast computerized tomography, 300 mg Iodine/mL: 1 to 2 mL/kg
Maximum dose: 3 mL/kg

Usual Pediatric Dose for Coronary Arteriography

2 years and older:
Cardiac chambers and related arteries, 370 mg Iodine/mL: 1 to 2 mL/kg
Maximum dose: 4 mL/kg

Renal Dose Adjustments

Use with caution.
-Use the lowest necessary dose in renal dysfunction.

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNING(S):
-NOT FOR INTRATHECAL USE
-Inadvertent intrathecal administration may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema

CONTRAINDICATIONS:
-Intrathecal use
-Preparatory dehydration (e.g. prolonged fasting and laxative use before administration) is contraindicated in pediatric patients due to the risk of renal failure.

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug is dialyzable; however, no dose adjustment guidelines have been reported.

Other Comments

Administration advice:
-Administer at or close to body temperature.

IV compatibility:
-Do not mix with other medications

General:
-Hydrate patients as appropriate prior to and after administration.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.