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Inqovi Side Effects

Generic name: cedazuridine / decitabine

Medically reviewed by Drugs.com. Last updated on Apr 13, 2024.

Note: This document provides detailed information about Inqovi Side Effects associated with cedazuridine / decitabine. Some dosage forms listed on this page may not apply specifically to the brand name Inqovi.

Applies to cedazuridine / decitabine: oral tablet.

Serious side effects of Inqovi

Along with its needed effects, cedazuridine/decitabine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cedazuridine / decitabine:

More common

  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody urine
  • blurred vision
  • body aches or pain
  • burning, numbness, painful, or tingling sensations
  • chest pain
  • chills
  • confusion
  • cough
  • coughing up blood
  • cracked lips
  • decreased frequency or amount of urine
  • diarrhea
  • difficult or labored breathing
  • difficulty in swallowing
  • dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • headache
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • nausea
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red spots on the skin
  • prolonged bleeding from cuts
  • rapid, shallow breathing
  • runny or stuffy nose
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • sweating
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Less common

  • fever sores on the skin
  • blue lips, fingernails, or skin

Rare

  • joint pain, stiffness, or swelling
  • stomach pain

Other side effects of Inqovi

Some side effects of cedazuridine / decitabine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • constipation
  • decreased appetite
  • difficulty in moving
  • falls
  • muscle pain, cramps, or stiffness
  • skin rash
  • trouble sleeping
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For healthcare professionals

Applies to cedazuridine / decitabine: oral tablet.

General

Myelosuppression (e.g., thrombocytopenia, neutropenia, anemia, febrile neutropenia) is the most frequent cause of dose reduction or interruption, occurring in 36% of patients. Permanent discontinuation due to myelosuppression (febrile neutropenia) occurred in 1% of patients. Myelosuppression and worsening neutropenia may occur more frequently in the first or second treatment cycles and may not necessarily indicate progression of underlying MDS.[Ref]

Immunologic

Musculoskeletal

musculoskeletal chest pain, flank pain, musculoskeletal stiffness, muscle strain, musculoskeletal discomfort (42%), arthralgia (e.g., arthralgia, back pain, neck pain, joint stiffness, pain in jaw, joint swelling, bursitis, joint range of motion decreased, joint injury (40%)[Ref]

Metabolic

Psychiatric

Hepatic

Respiratory

Other

Hematologic

Nervous system

Renal

Cardiovascular

Dermatologic

papular, rash pruritic, rash pustular, seborrheic dermatitis, skin exfoliation, skin irritation, stasis dermatitis, ulcerative keratitis (33%)

Gastrointestinal

ulceration, mucosal ulceration, nasal ulcer, noninfective gingivitis, oral mucosal blistering, oral mucosal erythema, pharyngeal erythema, pharyngeal ulceration, tongue ulceration, vulvitis) (41%), nausea (40%), diarrhea (37%)[Ref]

References

1. (2020) "Product Information. Inqovi (cedazuridine-decitabine)." Taiho Oncology, Inc.

Further information

Inqovi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.