Inqovi Side Effects

Generic name: cedazuridine / decitabine

Medically reviewed by Drugs.com. Last updated on Jun 29, 2024.

Note: This document provides detailed information about Inqovi.

Applies to cedazuridine / decitabine: oral tablet Side Effects associated with cedazuridine / decitabine. Some dosage forms listed on this page may not apply specifically to the brand name Inqovi.

Applies to cedazuridine / decitabine: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. This medicine may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Female patients should use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Male patients who have female partners should use effective birth control during treatment with this medicine and for at least 3 months after the last dose. If you think you have become pregnant or your partner has become pregnant while using this medicine, tell your doctor right away.

Cancer medicines can cause nausea or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.

This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
• Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
• Avoid contact sports or other situations where bruising or injury could occur.

If you plan to have children, talk with your doctor before using this medicine. Some men using this medicine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Inqovi

Along with its needed effects, cedazuridine/decitabine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cedazuridine / decitabine:

Other side effects of Inqovi

Some side effects of cedazuridine / decitabine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to cedazuridine / decitabine: oral tablet.

General adverse events

Myelosuppression (e.g., thrombocytopenia, neutropenia, anemia, febrile neutropenia) is the most frequent cause of dose reduction or interruption, occurring in 36% of patients. Permanent discontinuation due to myelosuppression (febrile neutropenia) occurred in 1% of patients. Myelosuppression and worsening neutropenia may occur more frequently in the first or second treatment cycles and may not necessarily indicate progression of underlying MDS.^[Ref]

Immunologic

• Very common (10% or more): Sepsis (e.g., sepsis, bacteremia, septic shock, endocarditis, pseudomonal bacteremia, staphylococcal bacteremia) (14%), cellulitis (e.g., cellulitis, catheter site cellulitis, infected bite) (12%)^[Ref]

Musculoskeletal

• Very common (10% or more): Myalgia (e.g., myalgia, pain in extremity, muscle spasms, pain, musculoskeletal pain, non-cardiac chest pain, muscular weakness,

musculoskeletal chest pain, flank pain, musculoskeletal stiffness, muscle strain, musculoskeletal discomfort (42%), arthralgia (e.g., arthralgia, back pain, neck pain, joint stiffness, pain in jaw, joint swelling, bursitis, joint range of motion decreased, joint injury (40%)^[Ref]

Metabolic

• Very common (10% or more): Glucose increased (54%), sodium decreased (30%), calcium decreased (30%), anorexia (24%), weight loss (10%)
• Uncommon (0.1% to 1%): Tumor lysis syndrome^[Ref]

Psychiatric

• Very common (10% or more): Insomnia (12%)^[Ref]

Hepatic

• Very common (10% or more): Transaminase increased (e.g., alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, gamma-glutamyltransferase increased, liver function test increased, transaminases increased) (21%), abdominal pain (e.g., abdominal pain upper, abdominal pain lower, epigastric discomfort, abdominal discomfort) (19%), vomiting (15%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (e.g., dyspnea, dyspnea exertional, hypoxia, wheezing, chronic obstructive pulmonary disease, tachypnea (38%) cough (e.g., cough, productive cough) (28%), upper respiratory tract infection (e.g., upper respiratory tract infection, nasopharyngitis, sinusitis, viral upper respiratory tract infection) (23%), pneumonia (e.g., pneumonia, pneumonitis, atypical pneumonia, lung infection) (21%)
• Postmarketing reports: Interstitial lung disease (decitabine)^[Ref]

Other

• Very common (10% or more): Fatigue/asthenia/lethargy (55%), edema (e.g., edema peripheral, peripheral swelling, swelling face, fluid overload, localized edema, face edema, edema, eye swelling, eyelid edema, fluid retention, periorbital swelling, scrotal edema, scrotal swelling) (30%), pyrexia (19%), fall (12%)^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (82%) Grade 3 or 4 occurring in 76%, leukocytes decreased (87%), platelet count decreased (82%), neutropenia (73%) with Grade 3 or 4 occurring in 71%. anemia (71%) with Grade 3 or 4 occurring in 55%, hemorrhage (e.g., contusion, epistaxis, petechiae, hematuria, conjunctival hemorrhage, mouth hemorrhage, purpura, angina bullosa hemorrhagica, gingival bleeding, hematoma, hemoptysis, eye contusion, hemorrhagic diathesis, increased tendency to bruise, vaginal hemorrhage, abdominal wall hematoma, blood blister, bone contusion, catheter site bruise, ecchymosis, genital hemorrhage, abdominal hematoma, oral mucosa hematoma, periorbital hemorrhage, procedural hemorrhage, pulmonary alveolar hemorrhage, retinal hemorrhage, scleral hemorrhage, thrombotic thrombocytopenic purpura, tongue hemorrhage, vessel puncture site hemorrhage) (43%), febrile neutropenia (33%)^[Ref]

Nervous system

• Very common (10% or more): Dizziness (e.g., dizziness, vertigo, postural dizziness, positional vertigo) (33%), headache (e.g., headache, sinus pain, sinus headache) (30%), neuropathy (e.g., hypoesthesia, paresthesia, neuropathy peripheral, gait disturbance, peripheral sensory neuropathy, ataxia, balance disorder, brachial plexopathy, carpal tunnel syndrome, radicular pain) (13%)^[Ref]

Renal

• Very common (10% or more): Renal impairment (e.g., blood creatinine increased, acute kidney injury, blood urea increased, blood creatine increased, renal failure) (18%)^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension (e.g., hypotension, blood pressure decreased, cardiogenic shock) (11%), arrhythmia (e.g., sinus tachycardia, atrial fibrillation, bradycardia, tachycardia, atrial flutter, sinus bradycardia, conduction disorder) (11%)^[Ref]

Dermatologic

• Very common (10% or more): Rash (e.g., maculopapular rash, rash, erythema, skin lesion, folliculitis, dermatitis, dermatitis acneiform, eczema, erythema multiforme, rash erythematous, seborrheic keratosis, skin ulcer, dermatitis allergic, dermatitis contact, eczema nummular, genital erythema, rash
• Common (1% to 10%): Acute febrile neutrophilic dermatosis (Sweet's syndrome)
• Postmarketing reports: Differentiation syndrome (decitabine)^[Ref]

papular, rash pruritic, rash pustular, seborrheic dermatitis, skin exfoliation, skin irritation, stasis dermatitis, ulcerative keratitis (33%)

Gastrointestinal

• Very common (10% or more): Constipation (44%), mucositis (e.g., oropharyngeal pain, stomatitis, mouth ulceration, proctalgia, oral pain, gingivitis, oral disorder, gingival pain, colitis, glossodynia, mouth swelling, pharyngitis, proctitis, duodenitis, enteritis, gingival discomfort, gingival swelling, lip disorder, lip

ulceration, mucosal ulceration, nasal ulcer, noninfective gingivitis, oral mucosal blistering, oral mucosal erythema, pharyngeal erythema, pharyngeal ulceration, tongue ulceration, vulvitis) (41%), nausea (40%), diarrhea (37%)^[Ref]

See also:

Further information

Inqovi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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