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Generic name: cedazuridine and decitabineSED-az-URE-i-deen-and-de-SIT-a-been ]
Drug class: Antineoplastic combinations

Medically reviewed by Judith Stewart, BPharm. Last updated on Nov 7, 2023.

What is Inqovi?

Inqovi contains a combination of cedazuridine and decitabine.

Inqovi is a prescription medicine that is used to treat treat adults with myelodysplastic syndromes (MDS, including chronic myelomonocytic leukemia (CMML). Myelodysplastic syndromes are types of blood or bone marrow disorders.

It is not known if Inqovi is safe or effective in children..


Inqovi affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.

Do not give Inqovi to other people, even if they have the same symptoms that you have. It may harm them.

Before taking this medicine

To make sure Inqovi is safe for you, tell your doctor if you have ever had::

You may need to have a negative pregnancy test before starting this treatment.

Cedazuridine and decitabine can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

Inqovi may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because the medicine can harm an unborn baby.

You should not breastfeed while using Inqovi and for at least 2 weeks after your last dose.

Inqovi is not approved for use by anyone younger than 18 years old.

How should I take Inqovi?

Take Inqovi exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Inqovi is given in a 28-day treatment cycle. You may need to use the medicine only during the first 5 days of each cycle. Your doctor will determine how long to treat you with this medicine.

Take Inqovi on an empty stomach, at least 2 hours before or 2 hours after a meal.

Take Inqovi at the same time each day.

Swallow the tablet whole and do not crush, chew, or break it.

Do not change your dose or stop using a medicine without your doctor's advice.

You may be given other medication to help prevent nausea or vomiting. Keep using that medication for as long as your doctor has prescribed.

If you vomit shortly after taking Inqovi, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Inqovi affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

Store Inqovi at room temperature away from moisture and heat. Keep each tablet in the blister pack until you are ready to take a dose.

Dosing information

Usual Adult Dose for Myelodysplastic Syndrome:

1 tablet (containing 100 mg cedazuridine and 35 mg decitabine) orally once daily on Days 1 through 5 of each 28-day cycle for a minimum of 4 cycles until disease progression or unacceptable toxicity; a complete or partial response may take longer than 4 cycles

-Consider administering antiemetics prior to each dose to minimize nausea and vomiting.

Use: For myelodysplastic syndromes (MDS), including previously treated and untreated, de novo and secondary MDS with the following French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, and chronic myelomonocytic leukemia [CMML]) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not take two doses at one time.

Finish taking all daily doses in the treatment cycle, even if you have to add an extra day to take the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Do not eat for at least 2 hours before or after taking this medicine.

Inqovi side effects

Get emergency medical help if you have signs of an allergic reaction to Inqovi: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Your treatments may be delayed or permanently discontinued if you have certain side effects.

Common Inqovi side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Inqovi?

Other drugs may interact with cedazuridine and decitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Inactive Ingredients

Lactose monohydrate, hypromellose, croscarmellose sodium, colloidal silicon dioxide and magnesium stearate. The film coating material contains polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide red.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Inqovi only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.