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Inqovi

Generic Name: decitabine and cedazuridine (tablets)

Medically reviewed by Judith Stewart, BPharm. Last updated on Jul 9, 2020.

What is Inqovi?

Inqovi is a prescription medicine used to treat adults with myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML). Your healthcare provider will determine if Inqovi can treat your type of MDS.

It is not known if this medicine is safe or effective in children.

Before taking Inqovi

Before taking Inqovi, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems
  • have liver problems
  • are pregnant or plan to become pregnant. Inqovi can harm your unborn baby. Tell your healthcare provider right
     away if you become pregnant or think you may be pregnant during treatment.
    Females who are able to become pregnant:
    • Your healthcare provider will check to see if you are pregnant before you start treatment.
    • You should use effective birth control during treatment, and for at least 6 months after your last dose.
    Males with female partners who are able to become pregnant should use effective birth control during treatment, and for 3 months after the last dose. Talk to your healthcare provider if you have questions about birth control options that are right for you.
  • are breastfeeding or plan to breastfeed. It is not known if Inqovi passes into breast milk. Do not breastfeed during treatment, and for at least 2 weeks after your last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take Inqovi?

  • Take Inqovi exactly as your healthcare provider tells you to.
  • Do not change your dose or stop taking Inqovi unless your healthcare provider tells you to.
  • Your healthcare provider may tell you to decrease your dose, temporarily stop, or completely stop taking Inqovi if you get certain side effects.
  • Take Inqovi one time a day at about the same time each day.
  • Take Inqovi on an empty stomach. Do not eat for at least 2 hours before and 2 hours after taking each dose.
  • Swallow the tablets whole. Do not cut, crush, or chew the tablet.
  • If you miss a dose, take your dose as soon as possible if it is within 12 hours of your usual time. Then, continue taking Inqovi at your scheduled time. If you missed a dose by more than 12 hours, do not take additional doses to make up for the missed dose. Take your next scheduled dose on the following day at your usual time.
  • If you vomit after taking a dose, do not take an additional dose. Take your next scheduled dose at your usual time.

Inqovi side effects

Inqovi may cause serious side effects, including:

  • Low blood cell counts. Low blood counts (white blood cells, platelets, and red blood cells) are common with Inqovi but can also be serious and lead to infections that may be life-threatening. If your blood cell counts are too low, your healthcare provider may need to delay treatment, lower your dose, or in some cases give you a medicine to help treat low blood cell counts. Your healthcare provider may need to give you antibiotic medicines to prevent or treat infections or fever while your blood cell counts are low. Your healthcare provider will check your blood cell counts before you start treatment and regularly during treatment.
    Call your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with Inqovi:
    • fever
    • chills
    • body aches
    • bruising more easily than usual

The most common side effects include:

  • low white blood cell count (leukopenia)
  • low platelets in your blood (thrombocytopenia)
  • low white blood cell count (neutropenia)
  • low red blood cell count (anemia)
  • tiredness
  • constipation
  • bleeding
  • muscle pain
  • pain or sores in your mouth or throat
  • joint pain
  • nausea
  • shortness of breath
  • diarrhea
  • rash
  • dizziness
  • fever with low white blood cell count (febrile neutropenia)
  • swelling of arms or legs
  • headache
  • cough
  • decreased appetite
  • upper respiratory tract infection
  • pneumonia
  • changes in liver function tests

Inqovi may affect fertility in men. Talk to your healthcare provider if this is a concern for you.
These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA 1088.

How should I store Inqovi?

  • Store Inqovi at room temperature between 68°F and 77°F (20°C and 25°C).
  • Do not store the tablets outside of the original blisters.
  • Talk to your healthcare provider about how to safely throw away (dispose of) Inqovi.

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Inqovi

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Inqovi?

Active ingredients: decitabine and cedazuridine
Inactive ingredients: lactose monohydrate, hypromellose, croscarmellose sodium, colloidal silicon dioxide and magnesium stearate. The film coating material contains polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide red.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Inqovi (cedazuridine / decitabine)

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