Generic Name: decitabine (de SIT a been)
Brand Name: Dacogen
What is decitabine?
Decitabine is a cancer medicine that is used to treat myelodysplastic syndromes (certain types of blood or bone marrow cancer).
Decitabine may also be used for purposes not listed in this medication guide.
Decitabine affects your immune system. You may get infections more easily. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, cough, sore throat, trouble breathing).
Before taking this medicine
Tell your doctor if you have ever had:
kidney disease; or
Decitabine can harm an unborn baby or cause birth defects if the mother or the father is using decitabine.
If you are a woman, do not use decitabine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 2 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using decitabine.
You should not breast-feed while using decitabine.
How is decitabine given?
Decitabine is given as an infusion into a vein. A healthcare provider will give you this injection.
In most cases, a decitabine injection is given every 8 hours for 3 days. This 3-day treatment is usually repeated every 6 weeks at least 4 times.
Decitabine affects your immune system. You may get infections more easily. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your decitabine injection.
What happens if I overdose?
Since decitabine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving decitabine?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
decitabine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Decitabine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fever, chills, body aches, cough, sore throat, flu symptoms;
easy bruising, unusual bleeding, purple or red spots under your skin;
pale skin, cold hands and feet;
slow heart rate, weak pulse, slow breathing; or
cough with mucus, chest pain, feeling short of breath.
Common side effects may include:
bruising or bleeding;
fever, and other signs of infection;
anemia, cough, trouble breathing;
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Decitabine dosing information
Usual Adult Dose for Myelodysplastic Syndrome:
TREATMENT REGIMEN OPTION 1:
15 mg/m2 IV over 3 hours; repeat every 8 hours for 3 days; repeat this cycle every 6 weeks; patients may be premedicated with standard antiemetic therapy
If hematologic recovery (ANC 1,000/mcL or greater and platelets 50,000/mcL or greater) from a previous treatment cycle requires more than 6 weeks, then the next cycle should be delayed and dosing temporarily reduced by following this algorithm:
-Recovery requiring more than 6, but less than 8 weeks: Delay dosing for up to 2 weeks and temporarily reduce the dose to 11 mg/m2 IV every 8 hours (33 mg/m2/day, 99 mg/m2/cycle) when restarting therapy
-Recovery requiring more than 8, but less than 10 weeks: Assess patient for disease progression (by bone marrow aspirates); in the absence of progression, the dose should be delayed up to 2 more weeks and then reduced to 11 mg/m2 IV every 8 hours (33 mg/m2/day, 99 mg/m2/cycle) when restarting therapy, then maintained or increased in subsequent cycles as clinically indicated
TREATMENT REGIMEN OPTION 2:
20 mg/m2 IV over 1 hour; repeat daily for 5 days; repeat this cycle every 4 weeks; patients may be premedicated with standard antiemetic therapy
If myelosuppression is present, subsequent treatment cycles should be delayed until there is hematologic recovery (ANC 1,000/mcL or greater and platelets 50,000/mcL or greater)
-With either regimen, it is recommended that patients be treated for a minimum of 4 cycles; however, a complete or partial response may take longer than 4 cycles.
-Perform complete blood and platelet counts prior to each cycle and as needed to monitor response and toxicity.
-Perform liver chemistries and serum creatinine prior to initiation of therapy.
Use: For the treatment of myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups
What other drugs will affect decitabine?
Other drugs may affect decitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 4.01.
More about decitabine
- Decitabine Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: antimetabolites
Other brands: Dacogen