HyperRHO S / D Mini-Dose Side Effects
Generic Name: rho (d) immune globulin
Note: This page contains information about the side effects of rho (d) immune globulin. Some of the dosage forms included on this document may not apply to the brand name HyperRHO S / D Mini-Dose.
For the Consumer
Applies to rho (d) immune globulin: injectable, powder for solution, solution
In addition to its needed effects, some unwanted effects may be caused by rho (d) immune globulin (the active ingredient contained in HyperRHO S / D Mini-Dose). In the event that any of these side effects do occur, they may require medical attention.
If any of the following side effects occur while taking rho (d) immune globulin, check with your doctor or nurse immediately:Rare:
- Bloody urine
- decreased frequency of urination or amount of urine
- increased blood pressure
- increased thirst
- loss of appetite
- lower back pain
- nausea or vomiting
- pale skin
- swelling of the face, fingers, or lower legs
- troubled breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- weight gain
Some of the side effects that can occur with rho (d) immune globulin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common:
- Soreness at the place of injection
For Healthcare Professionals
Applies to rho (d) immune globulin: injectable powder for injection, injectable solution, intramuscular powder for injection, intramuscular solution
Very common (10% or more): Chills (34.7%), pyrexia/increased body temperature (32.6%)
Uncommon (0.1% to 1%): Malaise
Very rare (less than 0.01%): Death
Frequency not reported: Shivering, weakness
Postmarketing reports: Chest pain, fatigue, edema[Ref]
Hemolytic reaction includes hypotension, nausea, chills, headache, and a decrease in haptoglobin and hemoglobin.[Ref]
Very rare (less than 0.01%): Disseminated intravascular coagulation
Frequency not reported: Intravascular hemolysis, hemolysis resulting in death, clinically compromising anemia, extravascular hemolysis, hemolytic reaction
Postmarketing reports: Hemoglobinemia, disseminated intravascular coagulation[Ref]
Uncommon (0.1% to 1%): Injection site swelling, injection site pain
Rare (less than 0.1%): Injection site erythema, injection site induration, injection site warmth, injection site pruritus, injection site rash[Ref]
Very common (10% or more): Headache (14.3%)
Uncommon (0.1% to 1%): Dizziness, vertigo[Ref]
Uncommon (0.1% to 1%): Nausea, vomiting
Rare (less than 0.1%): Diarrhea[Ref]
Rare (less than 0.1%): Tachycardia, hypotension
Frequency not reported: Increase in blood pressure
Postmarketing reports: Cardiac arrest, cardiac failure, myocardial infarction[Ref]
Uncommon (0.1% to 1%): Skin reaction, erythema, pruritus, pallor, rash
Postmarketing reports: Hyperhidrosis[Ref]
Rare (less than 0.1%): Arthralgia, back pain
Postmarketing reports: Myalgia, muscle spasm, pain in extremities[Ref]
Very common (10% or more): Increase in blood bilirubin (21.4%)
Postmarketing reports: Jaundice[Ref]
Rare (less than 0.1%): Hypersensitivity, anaphylactic shock, anaphylactic reaction[Ref]
The most common adverse events were chills, pyrexia, increased bilirubin, and headache.[Ref]
Rare (less than 0.1%): Dyspnea
Postmarketing reports: Acute respiratory distress syndrome, transfusion related acute lung injury[Ref]
Frequency not reported: Acute renal insufficiency
Postmarketing reports: Renal failure, renal impairment[Ref]
Uncommon (0.1% to 1%): Transient positive anti-C antibody test
Frequency not reported: Sensitization to repeated injections of human globulin[Ref]
Postmarketing reports: Hemoglobinuria, anuria, chromaturia, hematuria[Ref]
1. "Product Information. RhoGAM Ultra-Filtered Plus (RHo (D) immune globulin)." Kedrion Biopharma Inc, Cambridge, MA.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. "Product Information. Rhophylac (RHo (D) immune globulin)." ZLB Bioplasma Inc, Glendale, CA.
5. "Product Information. WinRho SDF (RHo (D) immune globulin)." Nabi, Boca Raton, FL.
6. "Product Information. HyperRHO S/D Full Dose (RHo (D) immune globulin)." Talecris Biotherapeutics, Research Triangle Park, NC.
7. "Product Information. BayRHo-D (RHo (D) immune globulin)." Bayer, West Haven, CT.
Not all side effects for HyperRHO S / D Mini-Dose may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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