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Glucarpidase Side Effects

Medically reviewed by Last updated on Feb 16, 2024.

Applies to glucarpidase: intravenous powder for solution.

Serious side effects of Glucarpidase

Along with its needed effects, glucarpidase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking glucarpidase:

Less common


Other side effects of Glucarpidase

Some side effects of glucarpidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


For Healthcare Professionals

Applies to glucarpidase: intravenous powder for injection.


The most common side effects reported were paresthesia, flushing, nausea and/or vomiting, hypotension, and headache.[Ref]


Very common (10% or more): Anti-glucarpidase antibodies (21%)[Ref]


Uncommon (0.1% to 1%): Hypersensitivity (including anaphylactic reactions)[Ref]


Common (1% to 10%): Flushing, hypotension

Uncommon (0.1% to 1%): Hypertension[Ref]


Uncommon (0.1% to 1%): Rash[Ref]


Common (1% to 10%): Nausea, vomiting

Uncommon (0.1% to 1%): Diarrhea[Ref]

Nervous system

Common (1% to 10%): Paresthesia, headache, burning sensation

Uncommon (0.1% to 1%): Tremor[Ref]


Uncommon (0.1% to 1%): Blurred vision[Ref]


Common (1% to 10%): Feeling hot[Ref]


Uncommon (0.1% to 1%): Throat irritation, throat tightness[Ref]


1. Product Information. Voraxaze (glucarpidase). BTG International Inc. 2012.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.