Glucarpidase Side Effects

Medically reviewed by Drugs.com. Last updated on May 31, 2024.

Applies to glucarpidase: intravenous powder for solution.

Precautions

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects. Be sure to keep all appointments.

Serious allergic reactions may occur during treatment with glucarpidase. Check with your doctor right away if you have a fever; chills; flushing of the face; headache; hives; itching; rash; tightness of the throat; tingling or numbness sensation; troubled breathing; rash; swelling of the face, tongue, and throat; or chest pain after you receive the medicine.

Serious side effects of glucarpidase

Along with its needed effects, glucarpidase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking glucarpidase:

Other side effects of glucarpidase

Some side effects of glucarpidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to glucarpidase: intravenous powder for injection.

General adverse events

The most common side effects reported were paresthesia, flushing, nausea and/or vomiting, hypotension, and headache.^[Ref]

Immunologic

• Very common (10% or more): Anti-glucarpidase antibodies (21%)^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity (including anaphylactic reactions)^[Ref]

Cardiovascular

• Common (1% to 10%): Flushing, hypotension
• Uncommon (0.1% to 1%): Hypertension^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting
• Uncommon (0.1% to 1%): Diarrhea^[Ref]

Nervous system

• Common (1% to 10%): Paresthesia, headache, burning sensation
• Uncommon (0.1% to 1%): Tremor^[Ref]

Ocular

• Uncommon (0.1% to 1%): Blurred vision^[Ref]

Other

• Common (1% to 10%): Feeling hot^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Throat irritation, throat tightness^[Ref]

See also:

Further information

Glucarpidase side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer