Glucarpidase Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 3, 2024.

Applies to glucarpidase: intravenous powder for solution.

Serious side effects of glucarpidase

Along with its needed effects, glucarpidase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking glucarpidase:

Less common side effects

• blurred vision
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• sweating
• unusual tiredness or weakness

Rare side effects

• cough
• difficulty with swallowing
• dizziness
• fever
• headache
• hives
• hoarseness
• irritation
• itching
• joint pain, stiffness, or swelling
• nervousness
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash
• redness of the skin
• shortness of breath
• slow or fast heartbeat
• swelling of the eyelids, face, lips, hands, or feet
• tightness in the chest
• troubled breathing or swallowing
• wheezing

Other side effects of glucarpidase

Some side effects of glucarpidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• feeling of warmth
• nausea
• redness of the face, neck, arms, and occasionally, upper chest
• vomiting

Rare side effects

• diarrhea
• shakiness in the legs, arms, hands, or feet
• sore throat
• trembling or shaking of the hands or feet

For healthcare professionals

Applies to glucarpidase: intravenous powder for injection.

General adverse events

The most common side effects reported were paresthesia, flushing, nausea and/or vomiting, hypotension, and headache.^[Ref]

Immunologic

• Very common (10% or more): Anti-glucarpidase antibodies (21%)^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity (including anaphylactic reactions)^[Ref]

Cardiovascular

• Common (1% to 10%): Flushing, hypotension
• Uncommon (0.1% to 1%): Hypertension^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting
• Uncommon (0.1% to 1%): Diarrhea^[Ref]

Nervous system

• Common (1% to 10%): Paresthesia, headache, burning sensation
• Uncommon (0.1% to 1%): Tremor^[Ref]

Ocular

• Uncommon (0.1% to 1%): Blurred vision^[Ref]

Other

• Common (1% to 10%): Feeling hot^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Throat irritation, throat tightness^[Ref]

Further information

Glucarpidase side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer