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Glucarpidase Dosage

Medically reviewed by Drugs.com. Last updated on Oct 8, 2019.

Applies to the following strengths: 1000 units

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Methotrexate Overdosage

Single IV injection of 50 Units/kg

Use: Treatment of toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.

Usual Pediatric Dose for Methotrexate Overdosage

Children 1 month of age or older: Single IV injection of 50 units/kg

Use: Treatment of toxic plasma methotrexate concentrations ( greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 1 month of age.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration advice:
-Administer intravenously as a bolus injection over 5 minutes.
-Flush intravenous line before and after administration.

Storage requirements: Store at 36F to 46F (2C to 8C)

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

General: Do not freeze

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.