Glucarpidase Dosage
Medically reviewed by Drugs.com. Last updated on Sep 28, 2021.
Applies to the following strengths: 1000 units
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Methotrexate Overdosage
Single IV injection of 50 Units/kg
Use: Treatment of toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.
Usual Pediatric Dose for Methotrexate Overdosage
Children 1 month of age or older: Single IV injection of 50 units/kg
Use: Treatment of toxic plasma methotrexate concentrations ( greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS: None
Safety and efficacy have not been established in patients younger than 1 month of age.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available.
Other Comments
Administration advice:
-Administer intravenously as a bolus injection over 5 minutes.
-Flush intravenous line before and after administration.
Storage requirements: Store at 36F to 46F (2C to 8C)
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
General: Do not freeze
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