Medically reviewed on November 27, 2017.
Applies to the following strengths: 1000 units
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Methotrexate Overdosage
Single IV injection of 50 Units/kg
Use: Treatment of toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.
Usual Pediatric Dose for Methotrexate Overdosage
Children 1 month of age or older: Single IV injection of 50 units/kg
Use: Treatment of toxic plasma methotrexate concentrations ( greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Data not available
Safety and efficacy have not been established in patients younger than 1 month of age.
Consult WARNINGS section for additional precautions.
Data not available.
-Administer intravenously as a bolus injection over 5 minutes.
-Flush intravenous line before and after administration.
Storage requirements: Store at 36F to 46F (2C to 8C)
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
General: Do not freeze
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Other brands: Voraxaze