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Glucarpidase Dosage

Medically reviewed on November 27, 2017.

Applies to the following strengths: 1000 units

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Methotrexate Overdosage

Single IV injection of 50 Units/kg

Use: Treatment of toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.

Usual Pediatric Dose for Methotrexate Overdosage

Children 1 month of age or older: Single IV injection of 50 units/kg

Use: Treatment of toxic plasma methotrexate concentrations ( greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 1 month of age.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration advice:
-Administer intravenously as a bolus injection over 5 minutes.
-Flush intravenous line before and after administration.

Storage requirements: Store at 36F to 46F (2C to 8C)

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

General: Do not freeze

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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