Glucarpidase (Intravenous)

Generic name: glucarpidase [ gloo-KARP-i-dase ]
Brand name: Voraxaze
Drug class: Antidotes

Medically reviewed by Drugs.com. Last updated on Sep 3, 2024.

Uses for glucarpidase

Glucarpidase injection is used to treat too much methotrexate concentration in the blood in patients with severe kidney disease.

This medicine is to be given only by or under the direct supervision of a doctor.

Before using glucarpidase

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of glucarpidase injection in children. However, safety and efficacy have not been established in children younger than 1 month of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of glucarpidase injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Leucovorin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper use of glucarpidase

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

If you are also using leucovorin, wait at least 2 hours before or after receiving glucarpidase injection.

Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.

Precautions while using glucarpidase

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects. Be sure to keep all appointments.

Serious allergic reactions may occur during treatment with glucarpidase. Check with your doctor right away if you have a fever; chills; flushing of the face; headache; hives; itching; rash; tightness of the throat; tingling or numbness sensation; troubled breathing; rash; swelling of the face, tongue, and throat; or chest pain after you receive the medicine.

Side Effects of glucarpidase

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Blurred vision
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
sweating
unusual tiredness or weakness

Rare

Cough
difficulty with swallowing
dizziness
fever
headache
hives
hoarseness
irritation
itching
joint pain, stiffness, or swelling
nervousness
pounding in the ears
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
redness of the skin
shortness of breath
slow or fast heartbeat
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
troubled breathing or swallowing
wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
feeling of warmth
nausea
redness of the face, neck, arms, and occasionally, upper chest
vomiting

Rare