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Fungizone For Tissue Culture Side Effects

Generic name: amphotericin b

Medically reviewed by Last updated on Feb 29, 2024.

Note: This document contains side effect information about amphotericin b. Some dosage forms listed on this page may not apply to the brand name Fungizone For Tissue Culture.

Applies to amphotericin b: powder for solution.


Intravenous route (Powder for Solution)

This drug should be used primarily for treatment of patients with progressive and potentially life-threatening fungal infections; it should not be used to treat noninvasive forms of fungal disease such as oral thrush, vaginal candidiasis and esophageal candidiasis in patients with normal neutrophil counts. Amphotericin B for injection should not be given at doses greater than 1.5 mg/kg. Exercise caution to prevent inadvertent overdosage, which can result in potentially fatal cardiac or cardiopulmonary arrest. Verify the product name and dosage pre-administration, especially if dose exceeds 1.5 mg/kg.

Serious side effects

Along with its needed effects, amphotericin b (the active ingredient contained in Fungizone For Tissue Culture) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amphotericin b:

More common

With intravenous injection

Less common or rare

With intravenous injection

With spinal injection

Other side effects

Some side effects of amphotericin b may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

With intravenous injection

Less common

With spinal injection

For Healthcare Professionals

Applies to amphotericin b: compounding powder, compounding powder for reconstitution, intravenous powder for injection, oral suspension.


Oral amphotericin B is not appreciably absorbed, even at high dosage, and systemic adverse effects have not been noted.

Intravenous amphotericin B will lead to some intolerance in most patients, even at less than the full therapeutic dose. Tolerance can be improved by treatment with antipyretics, antihistamines, or antiemetics. Meperidine may decrease the duration of chills and fever that accompany infusion. Small doses of IV adrenal corticosteroids just prior to or during infusion may decrease febrile reactions. Heparin and use of a pediatric scalp-vein needle may lessen thrombophlebitis incidence.[Ref]


Very common (10% or more): Renal function test abnormalities (including azotemia, hyposthenuria, renal tubular acidosis, and nephrocalcinosis), blood creatinine increased

Common (1% to 10%): Renal failure acute

Uncommon (0.1% to 1%): Renal impairment

Rare (less than 0.1%): Nephrogenic diabetes insipidus[Ref]

Renal function test abnormalities usually improve upon interruption of therapy, however some permanent impairment often occurs, especially in patients receiving large cumulative doses (over 5 grams). Concomitant diuretic use may predispose patient for renal impairment, whereas sodium repletion/supplementation may reduce nephrotoxicity occurrence.[Ref]


Very common (10% or more): Hypokalemia

Common (1% to 10%): Hypomagnesemia, decreased appetite

Rare (less than 0.1%): Hyperkalemia

Frequency not reported: Hypocalcemia[Ref]


Common (1% to 10%): Mild gastrointestinal distress, nausea, vomiting, diarrhea

Uncommon (0.1% to 1%): Abdominal pain upper

Rare (less than 0.1%): Dyspepsia, hemorrhagic gastroenteritis, melena

Frequency not reported: Transient yellowing of the teeth (oral route), cramping, epigastric pain[Ref]


Common (1% to 10%): Anemia

Uncommon (0.1% to 1%): Agranulocytosis, leukopenia, thrombocytopenia

Rare (less than 0.1%): Coagulopathy, eosinophilia, leukocytosis

Frequency not reported: Normochromic normocytic anemia[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Neuropathy peripheral

Rare (less than 0.1%): Encephalopathy, convulsion, tinnitus, vertigo[Ref]


Very rare (less than 0.01%): Anaphylactoid/anaphylactic reactions[Ref]


Cardiovascular side effects have been reported rarely. These have included hypotension, tachypnea, cardiac arrest, shock, cardiac failure, pulmonary edema, arrhythmia, including ventricular fibrillation, dyspnea, hypertension, and transient asystole. Thrombophlebitis has occurred in many patients because of the long duration of intravenous therapy usually required.[Ref]


Very common (10% or more): Chills

Uncommon (0.1% to 1%): Myalgia

Rare (less than 0.1%): Arthralgia[Ref]

Chills usually occur within 15 to 20 minutes after initiation of infusion[Ref]


Very common (10% or more): Dyspnea

Uncommon (0.1% to 1%): Bronchospasm

Frequency not reported: Tachypnea, wheezing, pulmonary edema, hypersensitivity pneumonitis[Ref]


Common (1% to 10%): Liver function test abnormalities, hepatic function abnormal

Uncommon (0.1% to 1%): Jaundice

Rare (less than 0.1%): Acute hepatic failure[Ref]


Very common (10% or more): Pyrexia

Rare (less than 0.1%): Deafness, pain and malaise, weight decreased

Frequency not reported: Hearing loss[Ref]


Common (1% to 10%): Rash

Rare (less than 0.1%): Urticaria, angioedema, rash maculopapular, pruritus, skin exfoliation, Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]


Common (1% to 10%): Injection site pain (with or without phlebitis or thrombophlebitis)[Ref]


Rare (less than 0.1%): Vision blurred, diplopia

Frequency not reported: Visual impairment[Ref]


Rare (less than 0.1%): Anuria, oliguria[Ref]


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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.