Skip to Content

Amphotericin b Pregnancy and Breastfeeding Warnings

Amphotericin b is also known as: Amphocin, Fungizone, Fungizone For Tissue Culture

Amphotericin b Pregnancy Warnings

Amphotericin B crosses the human placenta, with cord blood to maternal serum drug concentration ratios averaging up to 1.0. There were no reports of adverse fetal effects or congenital defects associated with amphotericin B in the Collaborative Perinatal Project. This study was a retrospective analysis of 50,282 mother-child pairs, 9 of whom experienced first trimester exposure to amphotericin B.

Amphotericin B has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Amphotericin B should only be given during pregnancy when benefit outweighs risk.

See references

Amphotericin b Breastfeeding Warnings

There are no data on the excretion of amphotericin B into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from amphotericin B, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Fungizone (amphotericin B)." Apothecon Inc, Plainsboro, NJ.
  2. "Product Information. Fungizone (amphotericin B)." Bristol-Myers Squibb, Princeton, NJ.
  3. Hager H, Welt SI, Cardasis JP, Alvarez S "Disseminated blastomycosis in a pregnant woman successfully treated with amphotericin-B: a case report." J Reprod Med 33 (1988): 485-8
  4. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297

References for breastfeeding information

  1. "Product Information. Fungizone (amphotericin B)." Bristol-Myers Squibb, Princeton, NJ.
  2. "Product Information. Fungizone (amphotericin B)." Apothecon Inc, Plainsboro, NJ.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.