Endal HD Side Effects

Generic Name: diphenhydramine / hydrocodone / phenylephrine

Note: This page contains information about the side effects of diphenhydramine / hydrocodone / phenylephrine. Some of the dosage forms included on this document may not apply to the brand name Endal HD.

For the Consumer

Applies to diphenhydramine / hydrocodone / phenylephrine: syrup

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness, excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor.

For Healthcare Professionals

Applies to diphenhydramine / hydrocodone / phenylephrine: oral suspension extended release, oral syrup

Nervous system

Nervous system side effects have included lightheadedness, nervousness, dizziness, drowsiness, sedation, mental clouding, headache, insomnia, tremors, weakness, lethargy, hallucinations, convulsions, impairment of mental and physical performance, anxiety, fear, dysphoria, psychic dependence, itchy and prickly sensations, and mood changes.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included difficulty swallowing, dry mouth, anorexia, nausea, vomiting, and heartburn.^[Ref]

Genitourinary

Genitourinary side effects have included ureteral spasm, spasm of vesicle sphincters, urinary retention, and dysuria.^[Ref]

Cardiovascular

Cardiovascular side effects have included pallor, tachycardia, palpitations, irregular heart beat, arrhythmias and cardiovascular collapse with hypotension.^[Ref]

Respiratory

Respiratory side effects have included respiratory difficulty and shortness of breath.^[Ref]

Ocular

Ocular side effects have included blurring of vision.^[Ref]

Dermatologic

Dermatologic side effects have included rare reports of dermatitis.^[Ref]

Not all side effects for Endal HD may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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