Endal CD (old formulation) Side Effects

Generic Name: codeine / diphenhydramine / phenylephrine

Note: This page contains information about the side effects of codeine / diphenhydramine / phenylephrine. Some of the dosage forms included on this document may not apply to the brand name Endal CD (old formulation).

For the Consumer

Applies to codeine / diphenhydramine / phenylephrine: solution, syrup

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mental or mood changes (eg, irritability); persistent trouble sleeping; restlessness; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor; vision changes or blurred vision.

For Healthcare Professionals

Applies to codeine / diphenhydramine / phenylephrine: oral syrup

Nervous system

Nervous system side effects have included drowsiness, dizziness, headache, nervousness, restlessness, impairment of mental performance, weakness, mental clouding, lethargy, anxiety, convulsions, CNS depression, tremor, and insomnia.^[Ref]

Psychiatric

Psychiatric side effects have included fear, dysphoria, psychic dependence, feeling of well-being, confusion, and mood changes.^[Ref]

Cardiovascular

Cardiovascular side effects have included tachycardia, palpitations, arrhythmias, change in heart rate, and cardiovascular collapse with hypotension.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included loss of appetite, nausea, constipation, dry mouth, anorexia, vomiting, and heartburn.^[Ref]

Genitourinary

Genitourinary side effects have included dysuria, polyuria, ureteral spasm, spasm of vesical sphincters, urinary disturbances, and urinary retention.^[Ref]

Respiratory

Respiratory side effects have included respiratory difficulty and respiratory depression.^[Ref]

Dermatologic

Dermatologic side effects have included increased sweating, pallor, skin hash, hives, swelling of face, and dermatitis.^[Ref]

Ocular

Ocular side effects have included blurring of vision and visual disturbances.^[Ref]

Not all side effects for Endal CD (old formulation) may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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