Advil Allergy Sinus
Generic Name: chlorpheniramine, ibuprofen, and pseudoephedrine (KLOR fen EER a meen, EYE bue pro fen, SOO doe ee FED rin)
Brand Names: Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold
Medically reviewed on May 21, 2018
What is Advil Allergy Sinus?
Advil Allergy Sinus contains a combination of chlorpheniramine, ibuprofen, and pseudoephedrine.
Advil Allergy Sinus is used to treat sneezing, itching, watery eyes, runny nose, stuffy nose, sinus congestion, cough, and pain or fever and other symptoms caused by the common cold or flu.
Advil Allergy Sinus may also be used for purposes other than those listed in this medication guide.
Do not give Advil Allergy Sinus to a child younger than 12 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Do not use Advil Allergy Sinus if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.
Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Ibuprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Ibuprofen can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
Ibuprofen can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning at any time while you are taking ibuprofen. Ibuprofen may be more likely to cause stomach bleeding in adults who are 60 or older.
Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes worsening stomach pain, black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
You should not use Advil Allergy Sinus if you are allergic to ibuprofen, chlorpheniramine or pseudoephedrine, or if you have a stomach ulcer or active bleeding in your stomach or intestines, polyps in your nose, or a history of allergic reaction to aspirin or other NSAIDs.
Before taking this medicine
Do not use Advil Allergy Sinus if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take Advil Allergy Sinus before the MAO inhibitor has cleared from your body. Do not use Advil Allergy Sinus if you are allergic to ibuprofen, chlorpheniramine or pseudoephedrine, or if you have:
a stomach ulcer or active bleeding in your stomach or intestines;
polyps in your nose; or
a history of allergic reaction to aspirin or other NSAIDs.
If you have certain conditions, you may need a dose adjustment or special tests to safely use Advil Allergy Sinus. Before you take this medication, tell your doctor if you have:
asthma, emphysema, bronchitis, or if you smoke;
a history of stomach problems, including heartburn, indigestion, stomach pain, and ulcers or bleeding;
heart disease, congestive heart failure, high blood pressure;
systemic lupus erythematosus (SLE);
- liver or kidney disease;
a thyroid disorder;
a bleeding or blood clotting disorder;
enlarged prostate or problems with urination; or
if you smoke.
Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Advil Allergy Sinus may be harmful to an unborn baby. Taking ibuprofen during the last 3 months of pregnancy may result in birth defects and prolonged labor and delivery. Do not take Advil Allergy Sinus during the last 3 months of pregnancy unless your doctor has told you to. Chlorpheniramine, ibuprofen, and pseudoephedrine passes into breast milk and may harm a nursing baby. Do not use Advil Allergy Sinus without telling your doctor if you are breast-feeding a baby.
Ibuprofen may be more likely to cause stomach bleeding in adults who are 60 or older. Do not give Advil Allergy Sinus to a child younger than 12 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
How should I take Advil Allergy Sinus?
Use Advil Allergy Sinus exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.
Take this medicine with food or milk if it upsets your stomach. Do not take more of Advil Allergy Sinus than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines.
The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of Advil Allergy Sinus needed to get relief from your cold or allergy symptoms. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Call your doctor if you have any new symptoms, or if you have a fever lasting longer than 3 days, stuffy nose lasting longer than 7 days, or pain lasting longer than 10 days. Do not take Advil Allergy Sinus for longer than 10 days without your doctor's advice.
If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.
Advil Allergy Sinus can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.
Store Advil Allergy Sinus at room temperature away from moisture and heat.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Since cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Overdose may cause nausea, vomiting, stomach pain, dizziness, feeling restless or nervous, blurred vision, sweating, breathing problems, or seizure (convulsions).
What should I avoid?
Advil Allergy Sinus can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol while taking Advil Allergy Sinus. If you drink more than 3 alcoholic beverages a day, ibuprofen may increase your risk of stomach bleeding.
Avoid becoming overheated or dehydrated during exercise and in hot weather.
Avoid taking Advil Allergy Sinus with diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.
Do not use any other over-the-counter cough, cold, or pain medication without first asking your doctor or pharmacist. Chlorpheniramine, ibuprofen, and pseudoephedrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of either medication. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or pain reliever.
Advil Allergy Sinus side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Advil Allergy Sinus: hives or blistering skin rash; wheezing or trouble breathing; faint; or swelling of your face, lips, tongue, or throat. Stop taking Advil Allergy Sinus seek medical attention or call your doctor at once if you have a serious side effect such as:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
worsening stomach pain, black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
fast, pounding, or uneven heartbeat;
redness or swelling;
severe dizziness, trouble sleeping, or nervousness;
easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure);
urinating less than usual or not at all;
skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or
fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).
Less serious Advil Allergy Sinus side effects may include:
upset stomach, nausea, heartburn, diarrhea, constipation;
bloating, gas, loss of appetite;
warmth, tingling, or redness under your skin;
dizziness, headache, feeling excited or restless;
skin itching or rash; or
ringing in your ears.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Advil Allergy Sinus?
Before taking Advil Allergy Sinus, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.
Tell your doctor about all other medications you use, especially:
a blood thinner such as warfarin (Coumadin);
steroids (prednisone and others);
a diuretic (water pill), or medicine to treat high blood pressure;
aspirin to prevent stroke or heart attack (ibuprofen can make aspirin less effective in protecting your heart and blood vessels);
a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;
antidepressants such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), and others; or
other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others.
This list is not complete and there may be other drugs that can interact with Advil Allergy Sinus. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Advil Allergy Sinus only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: upper respiratory combinations