EndaCof-DC Side Effects
Generic name: codeine / pseudoephedrine
Medically reviewed by Drugs.com. Last updated on Aug 18, 2022.
Note: This document contains side effect information about codeine / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name EndaCof-DC.
Applies to codeine / pseudoephedrine: oral capsule, oral liquid, oral syrup.
General
The more commonly reported adverse effects have included nausea, vomiting, and dizziness.[Ref]
Respiratory
Frequency not reported: Respiratory depression[Ref]
Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.[Ref]
Nervous system
Codeine
Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness
Frequency not reported: Restlessness, dizziness, weakness, headache, drowsiness, tremor[Ref]
Gastrointestinal
Codeine
Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation
Pseudoephedrine:
Frequency not reported: Nausea, vomiting, dry mouth[Ref]
Patients with chronic ulcerative colitis may experience increased colonic motility, while patients with acute ulcerative colitis have experienced toxic dilation with codeine use.[Ref]
Psychiatric
Codeine
Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation
Pseudoephedrine:
Frequency not reported: Hallucinations (particularly in children), anxiety, excitability, insomnia[Ref]
Cardiovascular
Codeine
Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression
Pseudoephedrine:
Frequency not reported: Tachycardia, palpitations, cardiac arrhythmias, hypertension, impaired circulation to the extremities[Ref]
Dermatologic
Codeine:
Frequency not reported: Rash
Pseudoephedrine:
Frequency not reported: Fixed drug eruption in the form of erythematous nodular patches, rash[Ref]
Genitourinary
Codeine
Frequency not reported: Oliguria, urinary retention, antidiuretic effect
Pseudoephedrine:
Frequency not reported: Urinary retention[Ref]
Hypersensitivity
Codeine
Frequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edema[Ref]
Ocular
Codeine
Frequency not reported: Visual disturbances
Pseudoephedrine:
Frequency not reported: Angle-closure glaucoma[Ref]
More about EndaCof-DC (codeine / pseudoephedrine)
Related treatment guides
References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
