EndaCof-DC Side Effects

Generic name: codeine / pseudoephedrine

Medically reviewed by Drugs.com. Last updated on Dec 24, 2023.

Note: This document provides detailed information about EndaCof-DC Side Effects associated with codeine / pseudoephedrine. Some dosage forms listed on this page may not apply specifically to the brand name EndaCof-DC.

Applies to codeine / pseudoephedrine: oral capsule, oral liquid, oral syrup.

Important warnings This medicine can cause some serious health issues

Codeine can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

This medicine is not for use in anyone under 18.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medications, codeine can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using codeine and pseudoephedrine and call your doctor at once if you have:

• noisy breathing, sighing, shallow breathing;

• a slow heart rate or weak pulse;

• severe dizziness or drowsiness;

• severe restlessness; or

• severe constipation.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Common side effects may include:

• drowsiness;

• blurred vision; or

• constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to codeine / pseudoephedrine: oral capsule, oral liquid, oral syrup.

General adverse events

The more commonly reported adverse effects have included nausea, vomiting, and dizziness.^[Ref]

Respiratory

Codeine:

• Frequency not reported: Respiratory depression^[Ref]

Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.^[Ref]

Nervous system

• Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness

Pseudoephedrine:

• Frequency not reported: Restlessness, dizziness, weakness, headache, drowsiness, tremor^[Ref]

Codeine

Gastrointestinal

• Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation

Pseudoephedrine:

• Frequency not reported: Nausea, vomiting, dry mouth^[Ref]

Patients with chronic ulcerative colitis may experience increased colonic motility, while patients with acute ulcerative colitis have experienced toxic dilation with codeine use.^[Ref]

Codeine

Psychiatric

• Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation

Pseudoephedrine:

• Frequency not reported: Hallucinations (particularly in children), anxiety, excitability, insomnia^[Ref]

Codeine

Cardiovascular

• Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression

Pseudoephedrine:

• Frequency not reported: Tachycardia, palpitations, cardiac arrhythmias, hypertension, impaired circulation to the extremities^[Ref]

Codeine

Dermatologic

Codeine:

• Frequency not reported: Rash

Pseudoephedrine:

• Frequency not reported: Fixed drug eruption in the form of erythematous nodular patches, rash^[Ref]

Genitourinary

• Frequency not reported: Oliguria, urinary retention, antidiuretic effect

Pseudoephedrine:

• Frequency not reported: Urinary retention^[Ref]

Codeine

Hypersensitivity

• Frequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edema^[Ref]

Codeine

Ocular

• Frequency not reported: Visual disturbances

Pseudoephedrine:

• Frequency not reported: Angle-closure glaucoma^[Ref]

Codeine

Further information

EndaCof-DC side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer