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Egrifta Side Effects

Generic Name: tesamorelin

Note: This page contains information about the side effects of tesamorelin. Some of the dosage forms included on this document may not apply to the brand name Egrifta.

In Summary

Common side effects of Egrifta include: injection site reaction, erythema at injection site, bruising at injection site, irritation at injection site, and pain at injection site. Other side effects include: limb pain, myalgia, peripheral edema, and decreased glucose tolerance. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tesamorelin: subcutaneous powder for solution

In addition to its needed effects, some unwanted effects may be caused by tesamorelin (the active ingredient contained in Egrifta). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking tesamorelin:

More common:
  • Difficulty with moving
  • muscle pain or stiffness
  • pain in the arms or legs
  • pain in the joints
Less common:
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, numbness, pain, or tingling in all fingers except the smallest finger
  • chest pain
  • dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • swelling of the joints
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

Minor Side Effects

Some of the side effects that can occur with tesamorelin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
  • muscle aching or cramping
Less common:
  • Acid or sour stomach
  • belching
  • bone pain
  • discouragement
  • feeling of warmth
  • feeling sad or empty
  • heartburn
  • indigestion
  • irritability
  • itching skin
  • lack of appetite
  • loss of interest or pleasure
  • muscle spasms
  • nausea
  • night sweats
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • sleeplessness
  • stiffness of the joints
  • stomach discomfort, upset, or pain
  • strain in the muscles
  • sudden sweating
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unable to sleep
  • upper abdominal or stomach pain
  • vomiting

For Healthcare Professionals

Applies to tesamorelin: subcutaneous powder for injection


Hypersensitivity side effects have included pruritus, erythema, flushing, urticaria, and other rash.[Ref]


Musculoskeletal side effects have included arthralgia, carpal tunnel syndrome, pain in extremity, myalgia, musculoskeletal pain, musculoskeletal stiffness, joint stiffness, muscle spasms, and joint swelling.[Ref]


Local side effects have included injection site reactions (erythema, pruritus, pain, urticaria, irritation, swelling, and hemorrhage).[Ref]

Nervous system

Nervous system side effects have included paresthesia, hypoesthesia and peripheral neuropathy.[Ref]


Gastrointestinal side effects have included nausea, vomiting, dyspepsia, and upper abdominal pain.[Ref]


Metabolic side effects have included hyperglycemia.[Ref]


Cardiovascular side effects have included palpitations, hypertension, hot flush and peripheral edema.[Ref]


Psychiatric side effects have included depression and insomnia.[Ref]


Dermatologic side effects have included rash, pruritus and night sweats.[Ref]


1. "Product Information. Egrifta (tesamorelin)." EMD Serono Inc, Rockland, MA.

Not all side effects for Egrifta may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.