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Deferoxamine Side Effects

For the Consumer

Applies to deferoxamine: injection powder for solution

Along with its needed effects, deferoxamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking deferoxamine:

More common
  • Bluish fingernails, lips, or skin
  • blurred vision or other problems with vision
  • convulsions (seizures)
  • difficulty with breathing or fast breathing
  • fast heartbeat
  • hearing problems
  • redness or flushing of the skin
Less common
  • Diarrhea
  • difficult urination
  • fever
  • leg cramps
  • nausea
  • stomach and muscle cramps
  • stomach discomfort
  • unusual bleeding or bruising
  • vomiting
Incidence not known
  • Agitation
  • coma
  • confusion
  • cough
  • decreased urine output
  • depression
  • difficulty with swallowing
  • dizziness
  • headache
  • hives
  • hostility
  • irritability
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • muscle twitching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • shortness of breath
  • skin rash
  • stupor
  • swelling of the face, ankles, or hands
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

Some side effects of deferoxamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to deferoxamine: injectable powder for injection

General

The most common adverse events were injection site reactions (pain, swelling, infiltration, erythema, pruritus, eschar/crust), and arthralgia/myalgia.[Ref]

Local

Very common (10% or more): Pain, swelling, infiltration, erythema, pruritus, eschar/crust at the injection site
Uncommon (0.1% to 1%): Vesicles, local edema, local burning[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia/myalgia
Common (1% to 10%): Growth retardation, bone disorder (e.g. metaphyseal dysplasia)
Frequency not reported: Muscle spasms, leg cramps, transient bone pain, hyperparathyroid bone disease[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Vomiting, abdominal pain
Very rare (less than 0.01%): Diarrhea[Ref]

Dermatologic

Common (1% to 10%): Urticaria
Very rare (less than 0.01%): Rash generalized, dermatitis medicamentosa[Ref]

Nervous system

Common (1% to 10%): Headache
Very rare (less than 0.01%): Neurological disturbances, dizziness, precipitation/exacerbation of aluminum-related dialysis encephalopathy (e.g. grand mal seizures, hallucinations, paranoid delusions, dialysis dementia), neuropathy peripheral, paresthesia
Frequency not reported: Convulsion[Ref]

Other

Common (1% to 10%): Pyrexia
Rare (less than 0.1%): Deafness neurosensory, tinnitus
Frequency not reported: Transient depression of serum calcium, reversible aphasia with visual loss and bradycardia[Ref]

Respiratory

Uncommon (0.1% to 1%): Asthma
Very rare (less than 0.01%): Acute respiratory distress, lung infiltration[Ref]

Hematologic

Very rare (less than 0.01%): Blood disorders (e.g. thrombocytopenia, leucopenia, eosinophilia)
Frequency not reported: Inhibition of DNA synthesis in T and B lymphocytes[Ref]

Cardiovascular

Rare (less than 0.1%): Hypotension, tachycardia, shock
Frequency not reported: Cardiac arrhythmias[Ref]

Genitourinary

Frequency not reported: Reddish-brown discoloration of the urine, dysuria[Ref]

Immunologic

Rare (0.01% to 0.1%): Mucormycosis
Very rare (less than 0.01%): Gastroenteritis Yersinia, unusual infections (e.g. Pneumocystis carinii, Yersinia, or Rhizopus)[Ref]

Ocular

Rare (less than 0.1%): Loss of vision, scotoma, retinal degeneration, optic neuritis, cataracts, decreased visual acuity, blurred vision, night blindness, visual field defects, chromatopsia, corneal opacities[Ref]

Hypersensitivity

Very rare (less than 0.01%): Anaphylactic shock, anaphylactoid reaction, angioneurotic edema, allergic skin reactions[Ref]

Renal

Very rare (less than 0.01%): Renal impairment (including a rise in serum creatinine)
Frequency not reported: Acute renal failure, renal tubular disorder, blood creatinine increased, aggravation of pyelonephritis[Ref]

Hepatic

Frequency not reported: Impaired hepatic function, increased transaminases[Ref]

Metabolic

Frequency not reported: Hypocalcemia[Ref]

Endocrine

Frequency not reported: Aggravation of hyperparathyroidism[Ref]

References

1. "Product Information. Deferoxamine Mesylate (deferoxamine)." Hospira Inc, Lake Forest, IL.

2. "Product Information. Desferal (deferoxamine)." Novartis Pharmaceuticals, East Hanover, NJ.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of deferoxamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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