Daurismo Side Effects

Generic name: glasdegib

Medically reviewed by Drugs.com. Last updated on Mar 10, 2025.

Note: This document provides detailed information about Daurismo Side Effects associated with glasdegib. Some dosage forms listed on this page may not apply specifically to the brand name Daurismo.

Applies to glasdegib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. It may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Female patients should use effective birth control during treatment with this medicine and for at least 30 days after the last dose. Male patients who have female partners should use effective birth control (even after a vasectomy) during treatment with this medicine and for at least 30 days after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

Your doctor will give you a pregnancy test within 7 days before you use this medicine to make sure you are not pregnant.

Do not donate blood or blood products or sperm while you are using this medicine and for at least 30 days after the last dose.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation.

If you plan to have children, talk with your doctor before using this medicine. Some men using this medicine have become infertile (unable to have children).

Cancer medicines can cause diarrhea, nausea, vomiting, or stomach pain in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these unwanted effects.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Daurismo

Along with its needed effects, glasdegib (the active ingredient contained in Daurismo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glasdegib:

Other side effects of Daurismo

Some side effects of glasdegib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to glasdegib: oral tablet.

Hematologic adverse events

• Very common (10% or more): Anemia (43%), hemorrhage (e.g., petechiae, epistaxis, hematoma, contusion, rectal hemorrhage, anal hemorrhage, ecchymosis, gingival bleeding, hematuria, mouth hemorrhage, purpura, cerebral hemorrhage, eye contusion, eye hemorrhage, gastric hemorrhage, GI hemorrhage, hematemesis, hemoptysis, implant site hematoma, injection site bruising, retroperitoneal hematoma, thrombotic thrombocytopenic purpura, tracheal hemorrhage, conjunctival hemorrhage, disseminated intravascular coagulation, eyelid hematoma, hematochezia, hemorrhage intracranial, hemorrhoidal hemorrhage, lower GI hemorrhage, retinal hemorrhage, subdural hematoma) (36%), febrile neutropenia (31%0, thrombocytopenia (30%), platelet count decreased (15%), white blood cell count decreased (11%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (e.g., pain in extremity, arthralgia, back pain, myalgia, musculoskeletal pain, musculoskeletal chest pain, neck pain, bone pain (30%), creatine phosphokinase (CPK) increased (16%), muscle tightness/spasm (15%)^[Ref]

Metabolic

• Very common (10% or more): Hyponatremia (54%), hypomagnesemia (33%), edema (e.g., edema peripheral, edema, fluid overload, fluid retention, swelling face) (30%), decreased appetite (21%), hypokalemia (15%), weight loss (13%)^[Ref]

Hepatic

• Very common (10% or more): AST increased (28%), alkaline phosphatase increased (23%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (e.g., dyspnea, hypoxia, bronchospasm, respiratory failure (23%), pneumonia (e.g., pneumonia, pneumonia aspiration, lung infection) (19%), cough (18%)^[Ref]

Other

• Very common (10% or more): Asthenia/fatigue (36%), pyrexia (18%)^[Ref]

Nervous system

• Very common (10% or more): Dysgeusia/ageusia (21%), dizziness (18%), headache (12%)^[Ref]

Renal

• Very common (10% or more): Creatinine increased (96%), renal insufficiency (e.g., acute kidney injury, blood creatinine increased, oliguria, renal failure) (19%)^[Ref]

Cardiovascular

• Very common (10% or more): Atrial arrhythmia (e.g., atrial fibrillation, bradycardia, tachycardia, sinus tachycardia) (13%), chest pain (e.g., chest pain, non-cardiac chest pain) (12%)
• Common (1% to 10%): QT interval prolongation^[Ref]

Dermatologic

• Very common (10% or more): Rash (e.g., rash, pruritus, erythema, skin ulcer, rash maculopapular, rash pruritic (20%)
• Common (1% to 10%): Alopecia^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (29%), mucositis (e.g., mucosal inflammation, oropharyngeal pain, stomatitis, anal ulcer, gingival pain, laryngeal inflammation, esophagitis, oral pain, aphthous ulcer, mouth ulceration, pharyngeal inflammation) (21%), constipation (20%), diarrhea (18%), vomiting (18%)
• Common (1% to 10%): Loose tooth, toothache^[Ref]

See also:

Frequently asked questions

• What type of cancer is Daurismo (glasdegib) used to treat?

Further information

Daurismo side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer