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Daurismo

Generic Name: glasdegib (glas DEG ib)
Brand Names: Daurismo

Medically reviewed by J. Stewart, BPharm. Last updated on Feb 11, 2019.

What is Daurismo?

See also: Xospata

Daurismo (glasdegib) is used in combination with cytarabine to treat acute myeloid leukemia (AML).

Daurismo and cytarabine treatment is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Daurismo use has not been studied in people with severe kidney problems or moderate-to-severe liver problems.

Important Information

Daurismo can cause severe birth defects or death of a baby if the mother or the father is taking this medicine at the time of conception or during pregnancy.

Both men and women should use effective birth control to prevent pregnancy while using Daurismo and for at least 30 days after your last dose.

Before taking this medicine

Daurismo can cause severe birth defects or death of a baby if the mother or the father is taking this medicine at the time of conception or during pregnancy.

  • If you are a woman who is able to get pregnant, you may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 30 days after your last dose.

  • If you are a man, use condoms when having sex with a woman who is able to get pregnant, even if you have had a vasectomy. Keep using condoms for at least 30 days after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Daurismo.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because glasdegib can harm an unborn baby.

Do not breast-feed while using Daurismo, and for at least 30 days after your last dose.

To make sure Daurismo is safe for you, tell your doctor if you have ever had:

  • heart problems;

  • long QT syndrome (in you or a family member); or

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

How should I take Daurismo?

Take Daurismo exactly as prescribed by your doctor, Follow all directions on your prescription label and read all medication guides or instruction sheets.

Daurismo is given in a 28-day treatment cycle, usually for a total of 6 cycles. Daurismo is taken by mouth, and cytarabine is given as an injection under your skin. Your doctor will determine how long to treat you with this medicine.

Take the medicine at the same time each day, with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

If you vomit shortly after taking Daurismo, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

You will need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

Store at room temperature away from moisture and heat.

Daurismo dosing information

Usual Adult Dose for Acute Myeloid Leukemia:

100 mg orally once a day on days 1 to 28 in combination with cytarabine 20 mg subcutaneously 2 times a day on days 1 to 10 of each 28-day cycle in the absence of unacceptable toxicity or loss of disease control; for patients without unacceptable toxicity, treat for a minimum of 6 cycles to allow time for clinical response

Use: This drug, in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients who are 75 years old or older or who have comorbidities that preclude use of intensive induction chemotherapy

Usual Geriatric Dose for Acute Myeloid Leukemia:

100 mg orally once a day on days 1 to 28 in combination with cytarabine 20 mg subcutaneously 2 times a day on days 1 to 10 of each 28-day cycle in the absence of unacceptable toxicity or loss of disease control; for patients without unacceptable toxicity, treat for a minimum of 6 cycles to allow time for clinical response

Use: This drug, in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients who are 75 years old or older or who have comorbidities that preclude use of intensive induction chemotherapy

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time or use more than one dose in a 12-hour period.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, dizziness, thirst, and little or no urination.

What should I avoid while taking Daurismo?

You must not donate blood or sperm while you are using Daurismo, and for at least 30 days after your last dose. If donated blood containing Daurismo is given to a pregnant woman, it could cause birth defects.

Daurismo side effects

Get emergency medical help if you have signs of an allergic reaction to Daurismo: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;

  • cough with mucus, chest pain, feeling short of breath;

  • easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots under your skin;

  • red or pink urine, rectal bleeding, bloody or tarry stools;

  • abnormal vaginal bleeding;

  • cough with bloody mucus or vomit that looks like coffee grounds;

  • redness in or around your eyes;

  • bleeding from a skin wound, needle injection, or surgical incision;

  • any bleeding that will not stop;

  • low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed, cold hands and feet; or

  • low white blood cell counts - fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Daurismo side effects may include:

  • bleeding;

  • low blood cell counts;

  • mouth sores, changes in your sense of taste;

  • loss of appetite, constipation;

  • rash;

  • muscle pain;

  • swelling in your arms or legs;

  • feeling tired; or

  • trouble breathing.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Daurismo?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Daurismo can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other drugs may interact with glasdegib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Daurismo only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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