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Daranide Side Effects

Generic Name: dichlorphenamide

Note: This page contains information about the side effects of dichlorphenamide. Some of the dosage forms included on this document may not apply to the brand name Daranide.

For the Consumer

Applies to dichlorphenamide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by dichlorphenamide (the active ingredient contained in Daranide). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dichlorphenamide:

Incidence not known:
  • Abdominal or stomach pain
  • black, tarry stools
  • blistering, peeling, or loosening of the skin
  • chest pain or discomfort
  • chills
  • confusion
  • convulsions
  • cough or hoarseness
  • dark urine
  • decreased urine
  • diarrhea
  • dilated neck veins
  • dizziness
  • drowsiness
  • dry mouth
  • extreme fatigue
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • increased thirst
  • irregular breathing
  • irregular heartbeat
  • itching or rash
  • joint or muscle pain
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • rapid, deep breathing
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • restlessness
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach cramps
  • swelling of the face, fingers, feet, or lower legs
  • swollen or painful glands
  • tightness in the chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • weight gain
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking dichlorphenamide, get emergency help immediately:

Symptoms of overdose:
  • Bloody or cloudy urine
  • bloody, black, or tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficult or painful urination
  • fainting
  • hearing loss
  • high fever
  • pale skin
  • shakiness and unsteady walk
  • shakiness in the legs, arms, hands, or feet
  • sudden decrease in the amount of urine
  • unsteadiness, trembling, or other problems with muscle control or coordination

Minor Side Effects

Some of the side effects that can occur with dichlorphenamide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in taste
  • difficulty with moving
  • general feeling of discomfort or illness
  • loss of taste
  • muscle pain or stiffness
  • muscle spasms
  • muscle twitching
  • pain in the joints
  • trouble performing routine tasks
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Incidence not known:
  • Decreased awareness or responsiveness
  • loss of memory
  • problems with memory
  • seeing, hearing, or feeling things that are not there
  • severe sleepiness

For Healthcare Professionals

Applies to dichlorphenamide: oral tablet


Postmarketing reports: Cardiac failure[Ref]


Common (1% to 10%): Rash, pruritus[Ref]


Common (1% to 10%): Diarrhea, nausea[Ref]


Postmarketing reports: Pancytopenia[Ref]


Frequency not reported: Hypersensitivity, anaphylaxis, idiosyncratic reactions[Ref]


Common (1% to 10%): Weight decreased
Frequency not reported: Hypokalemia, metabolic acidosis[Ref]


Common (1% to 10%): Muscle spasms, arthralgia, muscle twitching[Ref]

Nervous system

Very common (10% or more): Paresthesia (up to 44%), dysgeusia (up to 14%)
Common (1% to 10%): Headache, hypoesthesia, lethargy, dizziness
Postmarketing reports: Convulsion, syncope, tremor[Ref]


Frequency not reported: Falls
Postmarketing reports: Fetal death[Ref]


Very common (10% or more): Cognitive disorder (up to 14%), confusional state (up to 11%)
Postmarketing reports: Amnesia, hallucination, stupor, psychotic disorder[Ref]


Postmarketing reports: Nephrolithiasis, renal tubular necrosis[Ref]


Common (1% to 10%): Dyspnea, pharyngolaryngeal pain[Ref]


1. "Product Information. Keveyis (dichlorphenamide)." Taro Pharmaceuticals U.S.A. Inc, Hawthorne, NY.

Not all side effects for Daranide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.