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Cortisporin Ointment Side Effects

Generic Name: bacitracin / hydrocortisone / neomycin / polymyxin b topical

Note: This page contains information about the side effects of bacitracin / hydrocortisone / neomycin / polymyxin b topical. Some of the dosage forms included on this document may not apply to the brand name Cortisporin Ointment.

For the Consumer

Applies to bacitracin / hydrocortisone / neomycin / polymyxin b topical: ointment

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning, dryness, or itching of skin; worsening of condition.

Seek medical attention right away if any of these SEVERE side effects occur while taking bacitracin / hydrocortisone / neomycin / polymyxin b topical:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hearing or kidney problems; second infection.

For Healthcare Professionals

Applies to bacitracin / hydrocortisone / neomycin / polymyxin b topical: topical ointment


Hypersensitivity side effects associated with neomycin have included contact sensitization characterized by itching and swelling in 0.9% to 1% of patients.[Ref]

Nervous system

Nervous system side effects associated with neomycin have included ototoxicity.[Ref]


Renal side effects associated with neomycin have included nephrotoxicity.[Ref]


Dermatologic side effects associated with the use of topical corticosteroids have included burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria. These reactions are more likely with the use of occlusive dressings or with use over prolonged periods of time.[Ref]


Endocrine side effects of topical corticosteroids are rare. Glucose intolerance and hyperglycemia may be induced by corticosteroids. These drugs can rarely suppress the hypothalamic-pituitary-adrenal axis. This suppression is more likely when higher potency topical steroids are used over extensive areas and when occlusive dressings are used.[Ref]


1. "Product Information. Cortisporin Topical (hydrocortisone/neomycin/polymyxin B topical)." Monarch Pharmaceuticals Inc, Bristol, TN.

2. "Product Information. Cortisporin (bacitracin/HC/neomycin/polymyxin B topical)." Monarch Pharmaceuticals Inc, Bristol, TN.

Not all side effects for Cortisporin Ointment may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Cortisporin Ointment (bacitracin / hydrocortisone / neomycin / polymyxin b topical)

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