Cilgavimab / Tixagevimab Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Applies to cilgavimab / tixagevimab: parenteral injection for im use.

Important warnings This medicine can cause some serious health issues

As of January 26, 2023, FDA announced that tixagevimab/cilgavimab is currently not authorized for emergency use in the US.

For additional information, see [Web]

Side effects include:

Most common treatment-emergent adverse events occurring in ≥3% of individuals receiving tixagevimab 150 mg and cilgavimab 150 mg (median duration of follow-up of 83 days): Headache (6%), fatigue (4%), and cough (3%).

Overall safety profile of tixagevimab and cilgavimab at a median duration of follow-up of 6.5 months was similar.

Insomnia and dizziness reported in 1% of individuals receiving tixagevimab 300 mg and cilgavimab 300 mg; no other adverse effects reported at higher incidence rates than placebo.

For healthcare professionals

Applies to cilgavimab / tixagevimab: intramuscular solution.

Cardiovascular adverse events

• Uncommon (0.1% to 1%): Serious cardiovascular events (including myocardial infarction, cardiac failure), serious thromboembolic events
• Frequency not reported: Cardiac serious adverse events, acute myocardial infarction, cardiac failure leading to death, sudden cardiac death^[Ref]

All patients who experienced cardiac serious adverse events had cardiac risk factors and/or history of cardiovascular disease at baseline.^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity (included rash, urticaria)^[Ref]

Local

• Common (1% to 10%): Injection site reaction (included injection site pain, injection site erythema, injection site pruritus, injection site reaction, injection site induration)
• Frequency not reported: Injection-related reaction^[Ref]

Further information

Cilgavimab/tixagevimab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer