Calcitriol Side Effects
Medically reviewed by Drugs.com. Last updated on Feb 1, 2021.
Commonly reported side effects of calcitriol include: hypercalcemia, hypercalciuria, and increased serum creatinine. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to calcitriol: oral capsules, oral solution, parenteral injection
Side effects include:
Excessive vitamin D intake (late manifestations): Polyuria, polydipsia, anorexia, weight loss, nocturia, calcific conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated AST, elevated ALT, ectopic calcification, nephrocalcinosis, hypertension, cardiac arrhythmias, dystrophy, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections.
For Healthcare Professionals
Applies to calcitriol: injectable solution, oral capsule, oral liquid
Early signs of excessive vitamin D intake include weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, anorexia, abdominal pain, or stomach ache. Late signs include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated AST and ALT, ectopic calcification, nephrocalcinosis, hypertension, cardiac arrhythmias, dystrophy, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and rarely, overt psychosis.[Ref]
Very common (10% or more): Hypercalcemia
Uncommon (0.1% to 1%): Decreased appetite
Frequency not reported: Polydipsia, dehydration, weight loss, thirst, hyperphosphatemia, anorexia, hypercholesterolemia[Ref]
Common (1% to 10%): Hypercalciuria, urinary tract infection
Frequency not reported: Polyuria, nocturia, albuminuria[Ref]
Common (1% to 10%): Headache
Frequency not reported: Sensory disturbance, somnolence, metallic taste
Postmarketing reports: Seizure[Ref]
Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Vomiting
Common (1% to 10%): Rash
Frequency not reported: Urticaria, erythema, pruritus, erythema multiforme[Ref]
Frequency not reported: Elevated AST, elevated ALT[Ref]
Frequency not reported: Calcinosis, pyrexia, weakness, hyperthermia, ectopic calcification, dystrophy
Postmarketing reports: Chest pain[Ref]
Uncommon (0.1% to 1%): Blood creatinine increased
Frequency not reported: Elevated BUN, nephrocalcinosis, impairment of renal function[Ref]
Frequency not reported: Muscular weakness, growth retardation, muscle pain, bone pain[Ref]
Frequency not reported: Apathy, psychiatric disturbances, decreased libido, overt psychosis[Ref]
Frequency not reported: Pain on injection
Postmarketing reports: Bleeding at the venipuncture site[Ref]
Postmarketing reports: Hemolysis[Ref]
Frequency not reported: Conjunctivitis (calcific), photophobia[Ref]
Frequency not reported: Rhinorrhea[Ref]
1. "Product Information. Calcijex (calcitriol)." Abbott Pharmaceutical, Abbott Park, IL.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.