Cablivi Side Effects

Generic name: caplacizumab

Medically reviewed by Drugs.com. Last updated on May 4, 2024.

Note: This document provides detailed information about Cablivi Side Effects associated with caplacizumab. Some dosage forms listed on this page may not apply specifically to the brand name Cablivi.

Applies to caplacizumab: injectable kit.

Important warnings This medicine can cause some serious health issues

Caplacizumab can increase your risk of bleeding. Call your doctor if you have unusual bruising or bleeding, or any bleeding that will not stop.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• easy bruising or bleeding (nosebleeds, bleeding gums);

• unusual vaginal bleeding;

• any bleeding that will not stop; or

• signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

• nosebleeds, bleeding gums; or

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to caplacizumab: injectable kit.

General adverse events

The most frequently reported adverse reactions were epistaxis, headache, and gingival bleeding.^[Ref]

Respiratory

• Very common (10% or more): Epistaxis (29%)
• Common (1% to 10%): Dyspnea, hemoptysis^[Ref]

Nervous system

• Very common (10% or more): Headache (21%), paresthesia (12%)
• Common (1% to 10%): Subarachnoid hemorrhage, cerebral infarction^[Ref]

Gastrointestinal

• Very common (10% or more): Gingival bleeding (16%)
• Common (1% to 10%): Upper GI hemorrhage, rectal hemorrhage, abdominal wall hematoma^[Ref]

Immunologic

• Very common (10% or more): Pre-existing antibodies binding to this drug (63%)
• Common (1% to 10%): Treatment-emergent antibodies against this drug^[Ref]

Cardiovascular

• Very common (10% or more): Bleeding events (58%)^[Ref]

Other

• Very common (10% or more): Fatigue (15%), pyrexia (13%)^[Ref]

Dermatologic

• Very common (10% or more): Urticaria (14%)^[Ref]

Genitourinary

• Common (1% to 10%): Metrorrhagia, urinary tract infection, vaginal hemorrhage, hematuria, menorrhagia^[Ref]

Local

• Common (1% to 10%): Injection site hemorrhage, catheter site hemorrhage, injection site pruritus^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, myalgia^[Ref]

Ocular

• Common (1% to 10%): Eye hemorrhage^[Ref]

Further information

Cablivi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer