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Brimonidine / timolol ophthalmic Side Effects

Medically reviewed by Last updated on Mar 2, 2024.

Applies to brimonidine/timolol ophthalmic: ophthalmic solution.

Serious side effects

Along with its needed effects, brimonidine/timolol ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brimonidine / timolol ophthalmic:

More common

Less common

Get emergency help immediately if any of the following symptoms of overdose occur while taking brimonidine / timolol ophthalmic:

Symptoms of overdose

Other side effects

Some side effects of brimonidine / timolol ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to brimonidine / timolol ophthalmic: ophthalmic solution.


Very common (10% or more): Conjunctival hyperemia, burning sensation

Common (1% to 10%): Stinging sensation in the eye, allergic conjunctivitis, corneal erosion, superficial punctuate keratitis, eye pruritus, conjunctival folliculosis, visual disturbance, blepharitis, epiphora, eye dryness, eye discharge, eye pain, eye irritation, foreign body sensation, eyelid edema, eyelid pruritus, eyelid erythema

Uncommon (0.1% to 1%): Worsened visual acuity, conjunctival edema, conjunctivitis, vitreous floater, asthenopia, photophobia, papillary hypertrophy, eyelid pain, conjunctival blanching, corneal edema, corneal infiltrates, vitreous detachment, allergic contact dermatitis

Postmarketing reports: Blurred vision, keratoconjunctivitis sicca


-Frequency not reported: Iritis, iridocyclitis (anterior uveitis), miosis, cataract, conjunctival blanching, hordeolum, lid crusting, lid disorder


-Rare (less than 0.1%): Corneal calcification (with the use of phosphate containing eye drops in some patients with significantly damaged corneas)

-Frequency not reported: Keratitis, choroidal detachment following filtration surgery, decreased corneal sensitivity, corneal erosion, ptosis, diplopia, cystoid macular edema, pseudopemphigoid, refractive changes, blepharoptosis[Ref]


Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): Congestive heart failure, palpitations

Postmarketing reports: Arrhythmia, bradycardia, tachycardia, hypotension, pallor


-Frequency not reported: Vasodilation


-Frequency not reported: Chest pain, atrioventricular block, cardiac arrest, cardiac failure, Raynaud's phenomenon, cold hands and feet, claudication, worsening of angina pectoris[Ref]


Common (1% to 10%): Oral dryness

Uncommon (0.1% to 1%): Nausea, diarrhea


-Frequency not reported: Gastrointestinal symptoms


-Frequency not reported: Dyspepsia, abdominal pain, vomiting[Ref]



-Frequency not reported: Systemic allergic reactions, systemic lupus erythematosus, flu syndrome


-Frequency not reported: Systemic allergic reactions including angioedema, urticaria, localized and generalized rash, pruritus, anaphylactic reaction[Ref]

Nervous system

Common (1% to 10%): Somnolence, headache

Uncommon (0.1% to 1%): Dizziness, syncope, taste perversion

Postmarketing reports: Coma, lethargy


-Frequency not reported: Cerebrovascular accident, cerebral ischemia, increases in signs and symptoms of myasthenia gravis, paresthesia, disorientation, memory loss, tinnitus[Ref]


Common (1% to 10%): Depression


-Frequency not reported: Insomnia


-Frequency not reported: Insomnia, nightmare, behavioral changes and psychic disturbances including confusion, hallucination[Ref]


Uncommon (0.1% to 1%): Rhinitis, nasal dryness

Postmarketing reports: Respiratory depression


-Frequency not reported: Upper respiratory symptoms, dyspnea, apnea


-Frequency not reported: Bronchospasm (predominantly in patients with pre-existing bronchospastic disease), dyspnea, cough, upper respiratory infection, nasal congestion[Ref]



-Frequency not reported: Sexual dysfunction, decreased libido, Peyronie's disease, retroperitoneal fibrosis[Ref]


The commonly reported side effects were allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, and stinging.[Ref]


Postmarketing reports: Hypotonia


-Frequency not reported: Myalgia[Ref]


Common (1% to 10%): Asthenic conditions

Postmarketing reports: Facial erythema


-Frequency not reported: Edema, fatigue[Ref]



-Frequency not reported: Skin reaction including erythema, pruritus, rash


-Frequency not reported: Alopecia, psoriasiform rash or exacerbation of psoriasis, rash[Ref]


Common (1% to 10%): Abnormal Liver Function Tests[Ref]



-Frequency not reported: Masked symptoms of hypoglycemia in diabetes patients, hypercholesterolemia


-Frequency not reported: Hypoglycemia[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Product Information. Combigan (brimonidine-timolol ophthalmic). Allergan Inc. 2007.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.