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Avanafil Side Effects

In Summary

Commonly reported side effects of avanafil include: headache and flushing. Other side effects include: nasopharyngitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to avanafil: oral tablet

In addition to its needed effects, some unwanted effects may be caused by avanafil. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking avanafil:

Less common:
  • Blurred vision
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Rare
  • Arm, back, or jaw pain
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • chest pain or discomfort
  • chest tightness or heaviness
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • fast, irregular, pounding, or racing heartbeat or pulse
  • frequent urge to urinate
  • increased erection
  • lower back or side pain
  • nausea and vomiting
  • pain in the groin or genitals
  • pain, redness, or swelling in the arm or leg
  • rapid weight gain
  • sharp back pain just below the ribs
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Minor Side Effects

Some of the side effects that can occur with avanafil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Feeling of warmth
  • fever
  • muscle aches
  • redness of the face, neck, arms, and occasionally, upper chest
  • sore throat
  • stuffy or runny nose
Less common:
  • Acid or sour stomach
  • belching
  • body aches or pain
  • change in color vision
  • chills
  • cough
  • cough producing mucus
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • ear congestion
  • heartburn
  • indigestion
  • joint pain
  • loss of appetite
  • loss of voice
  • muscle pain or stiffness
  • pain or tenderness around the eyes and cheekbones
  • rash
  • shivering
  • sneezing
  • sweating
  • trouble sleeping
Rare
  • Anxiety
  • bloody nose
  • bone pain
  • burning feeling in the chest or stomach
  • confusion
  • cool, pale skin
  • depression
  • feeling of constant movement of self or surroundings
  • increased hunger
  • itching skin
  • muscle aching or cramping
  • muscle spasms
  • nightmares
  • seizures
  • sensation of spinning
  • shakiness
  • sleepiness or unusual drowsiness
  • slurred speech
  • swollen joints
  • tenderness in the stomach area

For Healthcare Professionals

Applies to avanafil: oral tablet

General

The most common side effects reported were headache, flushing, nasal and sinus congestion and back pain.[Ref]

Cardiovascular

Very common (10% or more): Flushing (up to 10.1%)
Common (1% to 10%): Hypertension, abnormal electrocardiogram
Uncommon (0.1% to 1%): Peripheral edema, angina, unstable angina, deep vein thrombosis, palpitations, hot flush, increased heart rate
Rare (less than 0.1%): Tachycardia, chest pain, increased blood pressure, cardiac murmur
Postmarketing reports: Hypotension[Ref]

Genitourinary

Uncommon (0.1% to 1%): Balanitis, increased erection
Rare (less than 0.1%): Penis disorder, spontaneous penile erection, genital pruritus, increased prostate specific antigen
Postmarketing reports: Priapism, hematuria, hematospermia, penile hemorrhage[Ref]

Dermatologic

Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, dyspepsia, nausea, constipation
Uncommon (0.1% to 1%): Gastritis, gastroesophageal reflux disease, stomach discomfort, vomiting, dyspepsia, nausea
Rare (less than 0.1%): Dry mouth, lower abdominal pain[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia
Uncommon (0.1% to 1%): Muscle spasms, musculoskeletal pain, myalgia, pain in extremity, muscle tightness
Rare (less than 0.1%): Flank pain[Ref]

Nervous system

Very common (10% or more): Headache (up to 12.1%)
Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Somnolence, vertigo, sinus headache
Rare (less than 0.1%): Psychomotor hyperactivity[Ref]

Psychiatric

Uncommon (0.1% to 1%): Depression, insomnia
Rare (less than 0.1%): Premature ejaculation, inappropriate affect[Ref]

Renal

Uncommon (0.1% to 1%): Hematuria, nephrolithiasis, pollakiuria, urinary tract infection
Rare (less than 0.1%): Blood urine present[Ref]

Respiratory

Common (1% to 10%): Nasal congestion, nasopharyngitis, upper respiratory infection (URI), bronchitis, sinusitis, sinus congestion
Uncommon (0.1% to 1%): Oropharyngeal pain, cough, exertional dyspnea, wheezing
Rare (less than 0.1%): Rhinorrhea, upper respiratory tract congestion[Ref]

Hematologic

Uncommon (0.1% to 1%): Epistaxis[Ref]

Hepatic

Uncommon (0.1% to 1%): Increased alanine aminotransferase
Rare (less than 0.1%): Increased blood bilirubin[Ref]

Immunologic

Common (1% to 10%): Influenza
Rare (less than 0.1%): Seasonal allergy[Ref]

Metabolic

Uncommon (0.1% to 1%): Hypoglycemia, increased blood glucose
Rare (less than 0.1%): Gout, Increased weight[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision, vision loss
Postmarketing reports: Non-arteritic anterior ischemic optic neuropathy (NAION)[Ref]

Other

Uncommon (0.1% to 1%): Fatigue, tinnitus
Rare (less than 0.1%): Asthenia, influenza-like illness, increased body temperature
Postmarketing reports: Loss of hearing[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Stendra (avanafil)." Vivus Inc, Mountain View, CA.

Not all side effects for avanafil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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