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Atrovent Nasal Side Effects

Generic Name: ipratropium nasal

Note: This document contains side effect information about ipratropium nasal. Some of the dosage forms listed on this page may not apply to the brand name Atrovent Nasal.

For the Consumer

Applies to ipratropium nasal: nasal spray

Along with its needed effects, ipratropium nasal (the active ingredient contained in Atrovent Nasal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ipratropium nasal:

For the 0.03% nasal sprayMore common Less common
  • Blurred vision
  • burning, dry, or itching eyes
  • discharge or excessive tearing
  • itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use
  • nasal dryness
  • nosebleeds
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • Pain or cramping in the abdomen or stomach
  • painful or difficult urination
Incidence not known
  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • tightness in the chest
For the 0.06% nasal spray used for 4 daysLess common
  • Nasal dryness
  • nosebleeds
  • Blurred vision
  • dizziness
  • eye redness or pain
  • fast, slow, or irregular heartbeat
  • pain or cramping in the abdomen or stomach
  • painful or difficult urination
  • ringing or buzzing in the ears
  • sore throat

Some side effects of ipratropium nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For the 0.03% nasal sprayLess common or rare
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • dry mouth or throat
  • increased nasal congestion or runny nose
  • nasal itching, burning, or irritation
  • nausea
For the 0.06% nasal sprayLess common or rare
  • Dry mouth or throat
  • increased nasal congestion

For Healthcare Professionals

Applies to ipratropium nasal: nasal spray


The most frequently reported side effects were nasal dryness, epistaxis, headache, nasal discomfort, and throat irritation.[Ref]

Additional side effects have been reported from published literature and/or postmarketing surveillance when this drug was used alone or in combination with albuterol, including: urinary retention, prostatic disorders, mydriasis, cases of precipitation or worsening of narrow-angle glaucoma, acute eye pain, ocular irritation, wheezing, dryness of the oropharynx, tachycardia, edema, gastrointestinal distress (diarrhea, nausea, vomiting), bowel obstruction, constipation, nasal discomfort, throat irritation, hypersensitivity, accommodation disorder, intraocular pressure increased, glaucoma, halo vision, conjunctival hyperemia, corneal edema, heart rate increased, bronchospasm, pharyngeal edema, gastrointestinal motility disorder, mouth edema, stomatitis, and pruritus. After oral inhalation in patients suffering from chronic obstructive pulmonary disease (COPD)/asthma, supraventricular tachycardia and atrial fibrillation have been reported.[Ref]


Common (1% to 10%): Upper respiratory tract infection, epistaxis, nasal dryness, nasal irritation, nasal congestion, rhinorrhea increased, rhinitis increased, posterior nasal drip, sneezing, nasal polyps, nasal edema, pharyngitis, sinusitis, nasal discomfort, ulcerative rhinitis
Uncommon (0.1% to 1%): Bronchospasm, laryngospasm, pharyngeal edema
Frequency not reported: Hoarseness, cough, nasal burning[Ref]


Uncommon (0.1% to 1%): Vision blurred, mydriasis, intraocular pressure increased, glaucoma, eye pain, halo vision, conjunctival hyperemia, corneal edema, accommodation disorder
Frequency not reported: Ocular irritation, conjunctivitis[Ref]


Frequency not reported: Irritation[Ref]

Nervous system

Common (1% to 10%): Headache, taste perversion
Uncommon (0.1% to 1%): Dizziness[Ref]


Uncommon (0.1% to 1%): Urinary retention[Ref]


Uncommon (0.1% to 1%): Supraventricular tachycardia, atrial fibrillation, heart rate increased
Rare (less than 0.1%): Palpitation
Frequency not reported: Tachycardia[Ref]


Common (1% to 10%): Nausea, dry mouth/throat, diarrhea, throat irritation
Uncommon (0.1% to 1%): Gastrointestinal motility disorder, stomatitis
Frequency not reported: Dry mouth/throat[Ref]


Uncommon (0.1% to 1%): Angioedema of throat/tongue/lips/face, rash
Rare (less than 0.1%): Urticaria, pruritus[Ref]


Uncommon (0.1% to 1%): Hypersensitivity, anaphylactic reaction[Ref]


Common (1% to 10%): Pain
Frequency not reported: Thirst, tinnitus[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Atrovent nasal spray (ipratropium nasal)." Boehringer-Ingelheim, Ridgefield, CT.

3. "Product Information. Ipratropium Bromide Nasal (ipratropium nasal)." West-Ward Pharmaceuticals Corporation (previously Roxane Laboratories Inc), Columbus, OH.

Some side effects of Atrovent Nasal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.