Atrasentan Side Effects

Applies to atrasentan: oral tablet.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• fluid retention--shortness of breath (even while lying down), swelling, rapid weight gain (especially in your face and midsection).

Your treatment may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• swelling of hands, legs, ankles and feet; or

• anemia (low red blood cells).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to atrasentan: oral tablet.

General adverse events

The most common adverse reactions in 5% or more patients included peripheral edema and anemia.^[Ref]

Cardiovascular

• Frequency not reported: Hypotension

Hematologic

• Very common (10% or more): Decreased hemoglobin (12%)
• Common (1% to 10%): Anemia

Hepatic

• Common (1% to 10%): Elevated ALT/AST (greater than 3 times the upper limit of normal)

Metabolic

• Very common (10% or more): Peripheral edema (10%)

Other

• Frequency not reported: Decreased sperm counts

See also:

Further information

Atrasentan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer