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ATNAA Side Effects

Generic Name: atropine / pralidoxime

Medically reviewed by Last updated on Sep 26, 2020.

Note: This document contains side effect information about atropine / pralidoxime. Some of the dosage forms listed on this page may not apply to the brand name ATNAA.

For the Consumer

Applies to atropine/pralidoxime: intramuscular solution auto-injector

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Chest pain or pressure or a fast heartbeat.
  • A heartbeat that does not feel normal.
  • Feeling confused.
  • Trouble passing urine.
  • Lowered interest in sex.
  • Not able to get or keep an erection.
  • Fast breathing.
  • Not able to pass urine or change in how much urine is passed.
  • Not sweating during activities or in warm temperatures.
  • Swelling of belly.
  • Trouble swallowing.
  • Very bad belly pain.
  • Very bad constipation.
  • Change in eyesight, eye pain, or very bad eye irritation.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Irritation where the shot is given.
  • Dry mouth.
  • Dry skin.
  • Dry eyes.
  • Blurred eyesight.
  • If bright lights bother your eyes.
  • Headache.
  • Dizziness.
  • Flushing.
  • Constipation.
  • Belly pain.
  • Upset stomach or throwing up.
  • Feeling sleepy.
  • Muscle weakness.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to atropine/pralidoxime: intramuscular solution


In cases of organophosphate poisoning, toxic effects from the poisoning may be difficult to differentiate from adverse reactions to this product.[Ref]


Frequency not reported: Tachycardia, palpitations, flushing, increased systolic and diastolic blood pressure, circulatory collapse, arrhythmias, myocardial infarction[Ref]

Nervous system

Frequency not reported: Headache, dizziness, tremor, drowsiness, locomotor difficulties, medullary paralysis[Ref]


Frequency not reported: Anhidrosis, maculopapular rash, petechial rash, scarletiniform rash[Ref]

Anhidrosis may produce heat intolerance and impair temperature regulation in hot environments.[Ref]


Frequency not reported: Dryness of the mouth, constipation, abdominal distension, nausea, vomiting, dysphagia, paralytic ileus[Ref]


Frequency not reported: Blurred vision, photophobia, diplopia, impaired accommodation, acute angle closure glaucoma[Ref]


Hypersensitivity is usually seen as skin rashes, on occasion progressing to exfoliation.[Ref]

Frequency not reported: Hypersensitivity, anaphylactic reaction[Ref]


Frequency not reported: Urinary hesitancy or retention, impotence[Ref]


Frequency not reported: Decreased renal function, transient elevations in creatinine phosphokinase[Ref]


Frequency not reported: Muscular weakness[Ref]


Frequency not reported: Muscle tightness and pain at the injection site[Ref]


Frequency not reported: Fatigue[Ref]


Frequency not reported: Elevations in SGOT and/or SGPT[Ref]

SGOT and SGPT levels returned to normal in about 2 weeks.[Ref]


Frequency not reported: Hyperventilation[Ref]


1. "Product Information. ATNAA (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.

2. "Product Information. DuoDote (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.

More about ATNAA (atropine / pralidoxime)

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.