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ATNAA Side Effects

Generic Name: atropine / pralidoxime

Note: This page contains information about the side effects of atropine / pralidoxime. Some of the dosage forms included on this document may not apply to the brand name ATNAA.

For the Consumer

Applies to atropine / pralidoxime: intramuscular solution

Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.

Get emergency medical help if you have any of these signs of an allergic reaction while taking atropine / pralidoxime: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • pounding heartbeats or fluttering in your chest;

  • painful or difficult urination;

  • trouble swallowing;

  • feeling like you might pass out;

  • confusion;

  • loss of movement in any part of your body;

  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); or

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects of atropine / pralidoxime may include:

  • dry mouth, dry nose, dry skin;

  • dry eyes, blurred vision;

  • increased sensitivity of your eyes to light;

  • headache;

  • dizziness, drowsiness;

  • muscle weakness;

  • constipation, stomach pain, bloating, nausea, vomiting;

  • loss of interest in sex, impotence; or

  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to atropine / pralidoxime: intramuscular solution

Nervous system

Nervous system side effects have included confusion, headache, dizziness, restlessness, tremor, fatigue, locomotor difficulties, delirium followed by hallucinations, depression, and, ultimately medullary paralysis and death.[Ref]


Cardiovascular side effects have included flushing, sinus tachycardia, palpitations, premature ventricular contractions, atrial flutter, atrial fibrillation, ventricular flutter, ventricular fibrillation, cardiac syncope, asystole, and myocardial infarction.[Ref]


Gastrointestinal side effects have included dysphagia, paralytic ileus, dryness of the mouth, constipation, abdominal pain, abdominal distention, nausea and vomiting.[Ref]


Ocular side effects have included blurred vision, dry eyes, photophobia, and acute angle closure glaucoma.[Ref]


Hypersensitivity side effects have included skin rashes which have progressed to exfoliation. Anaphylactic reaction and laryngospasm are rare.[Ref]


Musculoskeletal side effects have included muscular weakness.[Ref]


Dermatologic side effects have included maculopapular rash, petechial rash, and scarlatiniform rash. Anhidrosis may produce heat intolerance and impairment of temperature regulation in a hot environment.[Ref]


Genitourinary side effects have included urinary hesitancy or retention, loss of libido, and impotence.[Ref]


1. "Product Information. DuoDote (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.

Not all side effects for ATNAA may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about ATNAA (atropine / pralidoxime)

Consumer resources

Other brands: DuoDote

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.