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Atgam Side Effects

Generic Name: lymphocyte immune globulin, anti-thy (equine)

Note: This document contains side effect information about lymphocyte immune globulin, anti-thy (equine). Some of the dosage forms listed on this page may not apply to the brand name Atgam.

For the Consumer

Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection

Side effects include:

Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).

Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.

For Healthcare Professionals

Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution


General side effects have included fever, chills, herpes simplex reactivation, localized infection, systemic infection, possible serum sickness, lymphadenopathy, post-cervical lymphadenopathy, tender lymph nodes and night sweats.[Ref]


Hypersensitivity side effects have included anaphylaxis.[Ref]


Dermatologic side effects have included rash, pruritus, urticaria, wheal, flare, toxic epidermal necrosis and wound dehiscence.[Ref]


Musculoskeletal side effects have included arthralgia, chest, flank or back pain, leg pains, myalgia, joint stiffness, muscle ache, burning soles, burning palms, and foot sole pain.[Ref]


Gastrointestinal side effects have included GI bleeding or perforation, hiccoughs, epigastric pain, stomach pain, diarrhea, abdominal pain, stomatitis, laryngospasm, nausea and vomiting.[Ref]


Cardiovascular side effects have included hypertension, hypotension, tachycardia, congestive heart failure, edema, vasculitis and deep vein thrombosis, thrombophlebitis, clotted A-V fistula, myocarditis, cardiac irregularity, bradycardia, renal artery thrombosis, and iliac vein obstruction.[Ref]


Hematologic side effects have included thrombocytopenia, leukopenia, hepatosplenomegaly, neutropenia or granulocytopenia, anemia and thrombophlebitis.[Ref]


Respiratory side effects have included respiratory distress, dyspnea, apnea, pulmonary edema, bilateral pleural effusion, laryngospasm/edema, cough and sore mouth/throat.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, paresthesia, weakness or faintness, agitation/lethargy, listlessness, lightheadedness, seizures, malaise, confusion or disorientation, abnormal involuntary movement or tremor, possible encephalitis or post viral encephalopathy and rigidity.[Ref]


Local side effects have included pain at the infusion site.[Ref]


Renal side effects have included proteinuria.[Ref]


Ocular side effects have included periorbital edema.[Ref]


Metabolic side effects have included hyperglycemia.[Ref]


Hepatic side effects have included hepatosplenomegaly.[Ref]


1. "Product Information. Atgam (lymphocyte immune globulin, anti-thy (equine))." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Some side effects of Atgam may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.