Atgam Side Effects
Generic name: lymphocyte immune globulin, anti-thy (equine)
Medically reviewed by Drugs.com. Last updated on May 10, 2024.
Note: This document provides detailed information about Atgam Side Effects associated with lymphocyte immune globulin, anti-thy (equine). Some dosage forms listed on this page may not apply specifically to the brand name Atgam.
Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection.
Important warnings
This medicine can cause some serious health issues
- Should be used only by clinicians experienced in immunosuppressive therapy for the management of renal transplant or aplastic anemia patients.b
- Patients receiving antithymocyte globulin (equine) should be treated in facilities equipped and staffed with adequate laboratory and supportive medical resources.b
Side effects include:
Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).
Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.
For healthcare professionals
Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution.
Hypersensitivity adverse events
- Uncommon (0.1% to 1%): Anaphylactic reaction[Ref]
Dermatologic
- Very common (10% or more): Rash (26%)
- Common (1% to 10%): Urticaria, pruritus, vomiting, diarrhea, abdominal pain upper
- Uncommon (0.1% to 1%): Herpes simplex, allergic dermatitis, toxic epidermal necrolysis (TEN)
- Postmarketing reports: Hyperhidrosis[Ref]
Musculoskeletal
- Very common (10% or more): Arthralgia (17%)
- Common (1% to 10%): Chest pain, back pain[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea
- Uncommon (0.1% to 1%): Stomatitis
- Postmarketing reports: Abdominal pain, GI hemorrhage, GI perforation, oral pain[Ref]
Cardiovascular
- Common (1% to 10%): Thrombophlebitis, hypertension, hypotension, bradycardia, arteriovenous fistula thrombosis, tachycardia, iliac vein occlusion
- Postmarketing reports: Congestive heart failure, deep vein thrombosis, vasculitis[Ref]
Hematologic
- Very common (10% or more): Thrombocytopenia (22%), leukopenia (18%)
- Postmarketing reports: Anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, neutropenia, pancytopenia[Ref]
Respiratory
- Common (1% to 10%): Dyspnea
- Uncommon (0.1% to 1%): Pleural effusion, hiccups, laryngospasm, pulmonary edema
- Postmarketing reports: Apnea, cough, epistaxis, oropharyngeal pain[Ref]
Nervous system
- Common (1% to 10%): Headache, dizziness
- Uncommon (0.1% to 1%): Convulsion, encephalitis, paresthesia
- Postmarketing reports: Dyskinesia, Syncope, tremor[Ref]
Local
- Common (1% to 10%): Infusion site pain
- Postmarketing reports: Infusion site erythema, infusion site swelling[Ref]
Renal
- Uncommon (0.1% to 1%): Renal function test abnormal, renal artery thrombosis
- Postmarketing reports: Kidney rupture, renal failure acute[Ref]
Ocular
- Uncommon (0.1% to 1%): Periorbital edema[Ref]
Metabolic
- Uncommon (0.1% to 1%): Night sweats, hyperglycemia, proteinuria
- Postmarketing reports: Flank pain, muscle rigidity, myalgia, pain in extremity[Ref]
Hepatic
- Common (1% to 10%): Liver function test abnormal[Ref]
Immunologic
- Common (1% to 10%): Infection
- Uncommon (0.1% to 1%): Serum sickness
- Postmarketing reports: Hepatitis viral, localized infection, systemic infection[Ref]
Psychiatric
- Uncommon (0.1% to 1%): Agitation
- Postmarketing reports: Confusion, disorientation[Ref]
Other
- Very common (10% or more): Pyrexia (40%), chills (27%)
- Common (1% to 10%): Edema, lymphadenopathy, asthenia, malaise, wound dehiscence
- Postmarketing reports: Aplasia, pain[Ref]
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References
1. (2010) "Product Information. Atgam (lymphocyte immune globulin, anti-thy (equine))." Pfizer U.S. Pharmaceuticals Group
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Further information
Atgam side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.