Atgam Side Effects
Generic Name: lymphocyte immune globulin, anti-thy (equine)
Note: This page contains information about the side effects of lymphocyte immune globulin, anti-thy (equine). Some of the dosage forms included on this document may not apply to the brand name Atgam.
For the Consumer
Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection
Side effects include:
Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).
Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.
For Healthcare Professionals
Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution
General side effects have included fever, chills, herpes simplex reactivation, localized infection, systemic infection, possible serum sickness, lymphadenopathy, post-cervical lymphadenopathy, tender lymph nodes and night sweats.[Ref]
Hypersensitivity side effects have included anaphylaxis.[Ref]
Dermatologic side effects have included rash, pruritus, urticaria, wheal, flare, toxic epidermal necrosis and wound dehiscence.[Ref]
Musculoskeletal side effects have included arthralgia, chest, flank or back pain, leg pains, myalgia, joint stiffness, muscle ache, burning soles, burning palms, and foot sole pain.[Ref]
Gastrointestinal side effects have included GI bleeding or perforation, hiccoughs, epigastric pain, stomach pain, diarrhea, abdominal pain, stomatitis, laryngospasm, nausea and vomiting.[Ref]
Cardiovascular side effects have included hypertension, hypotension, tachycardia, congestive heart failure, edema, vasculitis and deep vein thrombosis, thrombophlebitis, clotted A-V fistula, myocarditis, cardiac irregularity, bradycardia, renal artery thrombosis, and iliac vein obstruction.[Ref]
Hematologic side effects have included thrombocytopenia, leukopenia, hepatosplenomegaly, neutropenia or granulocytopenia, anemia and thrombophlebitis.[Ref]
Respiratory side effects have included respiratory distress, dyspnea, apnea, pulmonary edema, bilateral pleural effusion, laryngospasm/edema, cough and sore mouth/throat.[Ref]
Nervous system side effects have included headache, dizziness, paresthesia, weakness or faintness, agitation/lethargy, listlessness, lightheadedness, seizures, malaise, confusion or disorientation, abnormal involuntary movement or tremor, possible encephalitis or post viral encephalopathy and rigidity.[Ref]
Local side effects have included pain at the infusion site.[Ref]
Renal side effects have included proteinuria.[Ref]
Ocular side effects have included periorbital edema.[Ref]
Metabolic side effects have included hyperglycemia.[Ref]
Hepatic side effects have included hepatosplenomegaly.[Ref]
1. "Product Information. Atgam (lymphocyte immune globulin, anti-thy (equine))." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Not all side effects for Atgam may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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