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Atgam Side Effects

Generic name: lymphocyte immune globulin, anti-thy (equine)

Medically reviewed by Last updated on Jan 17, 2023.

Note: This document contains side effect information about lymphocyte immune globulin, anti-thy (equine). Some dosage forms listed on this page may not apply to the brand name Atgam.

Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection.


  • Should be used only by clinicians experienced in immunosuppressive therapy for the management of renal transplant or aplastic anemia patients.b

  • Patients receiving antithymocyte globulin (equine) should be treated in facilities equipped and staffed with adequate laboratory and supportive medical resources.b

Side effects include:

Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).

Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.

For Healthcare Professionals

Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution.


Uncommon (0.1% to 1%): Anaphylactic reaction[Ref]


Very common (10% or more): Rash (26%)

Common (1% to 10%): Urticaria, pruritus, vomiting, diarrhea, abdominal pain upper

Uncommon (0.1% to 1%): Herpes simplex, allergic dermatitis, toxic epidermal necrolysis (TEN)

Postmarketing reports: Hyperhidrosis[Ref]


Very common (10% or more): Arthralgia (17%)

Common (1% to 10%): Chest pain, back pain[Ref]


Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Stomatitis

Postmarketing reports: Abdominal pain, GI hemorrhage, GI perforation, oral pain[Ref]


Common (1% to 10%): Thrombophlebitis, hypertension, hypotension, bradycardia, arteriovenous fistula thrombosis, tachycardia, iliac vein occlusion

Postmarketing reports: Congestive heart failure, deep vein thrombosis, vasculitis[Ref]


Very common (10% or more): Thrombocytopenia (22%), leukopenia (18%)

Postmarketing reports: Anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, neutropenia, pancytopenia[Ref]


Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Pleural effusion, hiccups, laryngospasm, pulmonary edema

Postmarketing reports: Apnea, cough, epistaxis, oropharyngeal pain[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Convulsion, encephalitis, paresthesia

Postmarketing reports: Dyskinesia, Syncope, tremor[Ref]


Common (1% to 10%): Infusion site pain

Postmarketing reports: Infusion site erythema, infusion site swelling[Ref]


Uncommon (0.1% to 1%): Renal function test abnormal, renal artery thrombosis

Postmarketing reports: Kidney rupture, renal failure acute[Ref]


Uncommon (0.1% to 1%): Periorbital edema[Ref]


Uncommon (0.1% to 1%): Night sweats, hyperglycemia, proteinuria

Postmarketing reports: Flank pain, muscle rigidity, myalgia, pain in extremity[Ref]


Common (1% to 10%): Liver function test abnormal[Ref]


Common (1% to 10%): Infection

Uncommon (0.1% to 1%): Serum sickness

Postmarketing reports: Hepatitis viral, localized infection, systemic infection[Ref]


Uncommon (0.1% to 1%): Agitation

Postmarketing reports: Confusion, disorientation[Ref]


Very common (10% or more): Pyrexia (40%), chills (27%)

Common (1% to 10%): Edema, lymphadenopathy, asthenia, malaise, wound dehiscence

Postmarketing reports: Aplasia, pain[Ref]

More about Atgam (lymphocyte immune globulin, anti-thy (equine))

Patient resources

Professional resources

Related treatment guides


1. "Product Information. Atgam (lymphocyte immune globulin, anti-thy (equine))." Pfizer U.S. Pharmaceuticals Group (2010):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.